Kouznetsov, Vladímir V.Sortino, MaximilianoZacchino, Susana A.Vargas Méndez, Leonor Y.Gupta, Mahabir P.2020-02-032020-02-032012-10-23http://hdl.handle.net/11634/21360Diverse α-naphthylamine derivatives were easily prepared from corresponding aldimines derived from commercially available α-naphthaldehyde and anilines or isomeric pyridinecarboxyaldehydes and α-naphthylamine. The secondary amines obtained were tested as possible antifungal and cytotoxic agents. The diverse N-aryl-N-[1-(1-naphthyl)but-3-enyl]amines obtained were active (IC50 < 10 µg/mL) against breast (MCF-7), non-small cell lung (H-460), and central nervous system (SF-268) human cancer cell lines, while N-(pyridinylmethyl)- naphthalen-1-amines resulted in activity against (MIC 25–32 µg/mL) some human opportunistic pathogenic fungi including yeasts, hialohyphomycetes, and dermatophytes.application/pdfAtribución-NoComercial-CompartirIgual 2.5 Colombiahttp://creativecommons.org/licenses/by-nc-sa/2.5/co/α-NaphthylaminesAntifungal propertiesCytotoxic agentshttps://doi.org/10.3797/scipharm.1209-03Generación de Nuevo Conocimiento: Artículos publicados en revistas especializadas - Electrónicos