Evaluación  de Candida albicans colonizante en cavidad bucal y los niveles de citoquinas de pacientes con cáncer sólido tratados con quimioterapia de la región caribe colombiana

Sánchez Molina, Marysol

Evaluación de Candida albicans colonizante en cavidad bucal y los niveles de citoquinas de pacientes con cáncer sólido tratados con quimioterapia de la región caribe colombiana

dc.contributor.advisor	Bettin Martínez, Alfonso Carlos
dc.contributor.advisor	Martínez Vega, Ruth Aralí
dc.contributor.author	Sánchez Molina, Marysol
dc.date.accessioned	2025-04-30T22:51:26Z
dc.date.available	2025-04-30T22:51:26Z
dc.description	Problema. La quimioterapia es un tratamiento para el cáncer que utiliza agentes terapéuticos no específicos, que afectan células de rápido recambio en los tejidos sanos y cancerosos, conduciendo a eventos adversos en cavidad bucal. El efecto varia debido a la inmunoestimulación y la inmunosupresión simultánea que puede ocurrir en respuesta al tumor y a la terapia. Objetivo: Evaluar Candida albicans colonizante en cavidad bucal y los niveles de citoquinas de pacientes con cáncer solido de la región caribe tratados con quimioterapia. Método: Estudio observacional, longitudinal y prospectivo, que incluyó 36 pacientes con cáncer sólido. Se evalúo el estado de salud oral y se obtuvieron 273 muestras de saliva, suero e hisopado bucal distribuidas en tres Tiempo 0, Tiempo 1 y Tiempo 2. Se realizó identificación microbiológica CHROMagar e ID Phoenix MD. Se analizaron las citocinas IL-10, IL-1 β, IL-6, IL12p70, TNF-, IL-17A, IL-21, IL-22, IL-23 con el Kit MILLIPLEX® Th17 humano. Se realizaron pruebas de Shapiro-Wilk, de Wilcoxon, Snedecor and Cochran, Kruskal-Wallis y U de Mann-Whitney. Resultados: Se encontraron diferencias significativas en los niveles de IL-1β en saliva (G1 vs G2: p=0.0361), TNFα en suero (G1 vs G2: p=0.0474), entre tiempos T0 y T1 en suero de la TNFa e IL12p70 Conclusión: La colonización de candida albicans tuvo una tendencia al aumento durante la quimioterapia. Entre tiempo T0 y T1 se observó una tendencia a la disminución de los niveles séricos de las citoquinas proinflamatorias TNF-a y IL12P70 en los pacientes colonizados
dc.description.abstract	Problem. Chemotherapy is a cancer treatment that uses non-specific therapeutic agents, which affect rapidly changing cells in healthy and cancerous tissues, leading to adverse events in the oral cavity. The effect varies due to immunostimulation and simultaneous immunosuppression that may occur in response to tumor and therapy. Objective: To evaluate colonizing Candida albicans in the oral cavity and cytokine levels in patients with solid cancer from the Caribbean region treated with chemotherapy. Methods: Observational, longitudinal and prospective study, which included 36 patients with solid cancer. Oral health status was evaluated and 273 saliva, serum and buccal swab samples were obtained, distributed in three Time 0, Time 1 and Time 2. Microbiological identification CHROMagar and ID Phoenix MD were performed. Cytokines IL-10, IL-1 β, IL-6, IL12p70, TNF-, IL-17A, IL-21, IL-21, IL-22, IL-23 were analyzed with the human MILLIPLEX® Th17 Kit. Shapiro-Wilk, Wilcoxon, Snedecor and Cochran, Kruskal-Wallis and Mann-Whitney U tests were performed. Results: Significant differences were found in the levels of IL-1β in saliva (G1 vs G2: p=0.0361), TNFα in serum (G1 vs G2: p=0.0474), between time T0 and T1 in serum TNFa and IL12p70 Conclusion: Candida albicans colonization had a tendency to increase during chemotherapy. Between time T0 and T1, a decreasing trend in serum levels of the proinflammatory cytokines TNF-a and IL12P70 was observed in colonized patients.
dc.description.degreelevel	Doctorado	spa
dc.description.degreename	Doctor en Odontología	spa
dc.description.domain	https://www.ustabuca.edu.co/
dc.format.mimetype	application/pdf
dc.identifier.citation	Sánchez Molina, M. (2025). Evaluación de Cándida albicans colonizante en cavidad bucal y los niveles de citoquinas de pacientes con cáncer sólido tratados con quimioterapia de la región caribe colombiana [Trabajo de Doctoreado, Universidad Santo Tomás]. Repositorio Institucional.
dc.identifier.instname	instname:Universidad Santo Tomás	spa
dc.identifier.reponame	reponame:Repositorio Institucional Universidad Santo Tomás	spa
dc.identifier.repourl	repourl:https://repository.usta.edu.co	spa
dc.identifier.uri	http://hdl.handle.net/11634/67200
dc.language.iso	spa
dc.publisher	Universidad Santo Tomás	spa
dc.publisher.branch	CRAI-USTA Bucaramanga
dc.publisher.faculty	Facultad de Odontología	spa
dc.publisher.program	Doctorado Odontología	spa
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dc.rights	Attribution-NonCommercial-NoDerivs 2.5 Colombia	en
dc.rights.accessrights	info:eu-repo/semantics/openAccess
dc.rights.coar	http://purl.org/coar/access_right/c_abf2
dc.rights.local	Abierto (Texto Completo)	spa
dc.rights.uri	http://creativecommons.org/licenses/by-nc-nd/2.5/co/
dc.subject.keyword	cáncer
dc.subject.keyword	cytokines
dc.subject.keyword	Candida albicans
dc.subject.lemb	Cavidad bucal
dc.subject.lemb	Cáncer bucal
dc.subject.lemb	Análisis de información
dc.subject.lemb	Quimioterapia
dc.subject.proposal	citoquinas
dc.subject.proposal	Candida albicans
dc.subject.proposal	cáncer
dc.title	Evaluación de Candida albicans colonizante en cavidad bucal y los niveles de citoquinas de pacientes con cáncer sólido tratados con quimioterapia de la región caribe colombiana
dc.type	doctoral thesis
dc.type.category	Formación de Recurso Humano para la Ctel: Tesis de Doctorado
dc.type.coar	http://purl.org/coar/resource_type/c_db06
dc.type.coarversion	http://purl.org/coar/version/c_ab4af688f83e57aa
dc.type.drive	info:eu-repo/semantics/doctoralThesis
dc.type.local	Tesis doctoral	spa
dc.type.version	info:eu-repo/semantics/acceptedVersion