Síntesis y caracterización de un polímero de coordinación de zinc y ácido p-tereftálico con potencial aplicación en la liberación controlada de ibuprofeno

Abstract

Many current scientific researches focus on the development of controlled release systems to meet the need for local and efficient therapy. Compared to conventional routes of administration are the Modified Release Pharmaceutical Forms (FFLM) that have recently had their field of action in biomedicine. Research systems include organic polymers, zeolites and mesoporous silicates. However, inorganic–organic hybrid materials are the subject of recent studies, due to their increased storage capacity and modifiable structures that make them highly effective for supporting the sustained release of an analgesic drug. Among the nonsteroidal anti-inflammatory analgesic drugs (NSAIDs), ibuprofen stands out for treating acute pictures of fever and arthritis. In addition, it is one of the most widely consumed drugs in the world and is the highest grossing without a prescription. In this grade work a coordination polymer was obtained by solvothermal synthesis formed by the union of zinc ions as a metal center and terephthalic acid as ligand. Subsequently, ibuprofen was incorporated into the synthesized MOF structure. All materials were characterized by instrumental techniques (IR, UV-Vis, XRD). Finally, the drug's release kinetics profile was performed in the obtained structure, by in vitro release in solution buffers.