Evaluación de nanopartículas de sílice mesoporosa obtenida de la cascarilla de arroz como sistema de liberación controlada del letrozol

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dc.contributor.advisorCandela Soto, Angélica María
dc.contributor.authorGarcía Niño, Laura Milena
dc.contributor.corporatenameUniversidad Santo Tomásspa
dc.coverage.campusCRAI-USTA Bucaramangaspa
dc.date.accessioned2021-07-13T00:14:50Z
dc.date.available2021-07-13T00:14:50Z
dc.date.issued2021-07-07
dc.descriptionEl uso de los medicamentos convencionales ha traído consigo diferentes efectos secundarios en el cuerpo humano como resultado a la liberación inmediata del principio activo. Adicionalmente, la cascarilla de arroz es un desecho agrícola generado en grandes cantidades provocando problemas de contaminación. Por ende, esta propuesta de investigación evaluó la cinética de liberación del letrozol empleando como material de soporte las nanopartículas de sílice mesoporosa obtenidas a partir de la cascarilla de arroz. La síntesis de las nanopartículas se realizó mediante el método Sol-gel y se caracterizó mediante FTIR y TEM. Los resultados obtenidos evidenciaron una liberación controlada con acción prolongada, ajustándose mejor al modelo cinético de primer orden debido a que el letrozol es liberado de forma proporcional al gradiente de concentración.spa
dc.description.abstractThe use of conventional medications has brought with it different side effects in the human body as a result of the immediate release of the active substance. In addition, rice husk is an agricultural waste generated in large quantities causing pollution problems. Therefore, this research proposal assessed the release kinetics of letrozole using as support material the mesoporous silica nanoparticles obtained from the rice husk. The synthesis of the nanoparticles was performed using the Sol-gel method and characterized by FTIR and TEM. The results obtained showed a controlled release with prolonged action, better adjusting to the first order kinetic model because letrozole is released proportionally to the concentration gradient.spa
dc.description.degreelevelPregradospa
dc.description.degreenameQuímico Ambientalspa
dc.description.domainhttps://www.ustabuca.edu.co/spa
dc.format.mimetypeapplication/pdfspa
dc.identifier.citationGarcía Niño, L. M. (2021). Evaluación de nanopartículas de sílice mesoporosa de la cascarilla de arroz como sistema de liberación controlada del letrozol. [Tesis de pregrado]. Universidad Santo Tomás, Bucaramanga, Colombia.spa
dc.identifier.instnameinstname:Universidad Santo Tomásspa
dc.identifier.reponamereponame:Repositorio Institucional Universidad Santo Tomásspa
dc.identifier.repourlrepourl:https://repository.usta.edu.cospa
dc.identifier.urihttp://hdl.handle.net/11634/34871
dc.language.isospaspa
dc.publisherUniversidad Santo Tomásspa
dc.publisher.facultyFacultad de Química Ambientalspa
dc.publisher.programPregrado Química Ambientalspa
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dc.relation.referencesWeissig, V., Pettinger, T. K., & Murdock, N. (2014). Nanopharmaceuticals (part 1): products on the market. International journal of nanomedicine, 9, 4357–4373. https://doi.org/10.2147/IJN.S46900spa
dc.relation.referencesWorathanakul, P., Payubnop, W., & Muangpet, A. (2009). Characterization for post-treatment effect of bagasse ash for silica extraction. World Academy of Science, Engineering and Technology, 56(August 2009), 360–362. https://doi.org/10.5281/zenodo.1062185spa
dc.relation.referencesYanes, R. E., Lu, J., & Tamanoi, F. (2012). Nanoparticle-Based Delivery of siRNA and miRNA for Cancer Therapy (Vol. 32, pp. 185–203). https://doi.org/10.1016/B978-0-12-404741-9.00009-Xspa
dc.relation.referencesYun, Y. H., Lee, B. K., & Park, K. (2015). NU SC. Journal of Controlled Release. https://doi.org/10.1016/j.jconrel.2015.10.005spa
dc.rights.accessrightsinfo:eu-repo/semantics/closedAccess
dc.rights.coarhttp://purl.org/coar/access_right/c_14cb
dc.rights.localAcceso cerradospa
dc.subject.keywordControlled releasespa
dc.subject.keywordLetrozolespa
dc.subject.keywordMesoporous silica nanoparticlesspa
dc.subject.keywordRice huskspa
dc.subject.lembArroz - Abonos y fertilizantesspa
dc.subject.lembResiduos agrícolasspa
dc.subject.lembCascarilla de arrozspa
dc.subject.proposalCascarilla de arrozspa
dc.subject.proposalLetrozolspa
dc.subject.proposalLiberación controladaspa
dc.subject.proposalNanopartículas de sílice mesoporosaspa
dc.titleEvaluación de nanopartículas de sílice mesoporosa obtenida de la cascarilla de arroz como sistema de liberación controlada del letrozolspa
dc.typebachelor thesis
dc.type.categoryFormación de Recurso Humano para la Ctel: Trabajo de grado de Pregradospa
dc.type.coarhttp://purl.org/coar/resource_type/c_7a1f
dc.type.coarversionhttp://purl.org/coar/version/c_ab4af688f83e57aa
dc.type.driveinfo:eu-repo/semantics/bachelorThesis
dc.type.localTesis de pregradospa
dc.type.versioninfo:eu-repo/semantics/acceptedVersion

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