Desarrollo de emulsiones de limoneno como productos larvicidas para el control de las larvas de mosquitos Aedes aegypti

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dc.contributor.advisorVargas Méndez, Leonor Yamile
dc.contributor.authorJaramillo Pérez, Víctor Mario
dc.date.accessioned2021-03-16T21:19:59Z
dc.date.available2021-03-16T21:19:59Z
dc.date.issued2021-03-13
dc.descriptionLos productos naturales han tomado un nuevo impulso en la búsqueda de compuestos capaces de controlar el Aedes aegypti. En esta investigación, los aceites esenciales (AEs) del genero Citrus y sus metabolitos mayoritarios, R-(+) y S-(-)-limoneno, se evaluaron como agentes larvicidas. El S-(-)-limoneno, fue el larvicida más activo con CL50 de 13.34; 15.97 y 19.22 ppm sobre las cepas Rockefeller, Piedecuesta y Bucaramanga respectivamente; fue encapsulado con Tween 80 y propilenglicol, formando micelas de tamaño nanométrico, inferior a 10 nm. La evaluación de la emulsión como larvicida dio una CL100 de 30 ppm. Los AEs y los metabolitos fueron capaces de inhibir la acetilcolinesterasa con valores entre 144.5 µg/mL y 256.0 µg/mL. El R-(+)-limoneno fue moderadamente tóxico sobre el organismo no objetivo Danio rerio con CL50 de 22.44 µg/mL.spa
dc.description.abstractBotanical products have gained significant momentum in the quest of compounds capable of controlling Aedes aegypti. In this research, essential oils (EOs) from the genus Citrus and their major secondary metabolites, R-(+) and S-(-)-limonene, were evaluated as larvicide agents. S-(-)-limonene was the most active larvicide as it showed LC50 of 13.34; 15.97 and 19.22 ppm over the Rockefeller, Piedecuesta and Bucaramanga Strains, respectively. It was encapsulated with both Tween 80 and Propylene glycol, and as a result, it developed nanometric-scaled emulsions of less than 10 nm. The assessment of the emulsion as a larvicide displayed an LC100 of 30 ppm. The EOs and the secondary metabolites were capable of inhibiting acetylcholinesterase by using values between 144.5 µg/mL and 256.0 µg/mL. R-(+)-limonene had a moderate toxicity of LC50 22.44 µg/mL over the non-target organism Danio rerio.spa
dc.description.degreelevelMaestríaspa
dc.description.degreenameMagister en Ciencias y Tecnologías Ambientalesspa
dc.description.domainhttps://www.ustabuca.edu.co/spa
dc.format.mimetypeapplication/pdf
dc.identifier.citationJaramillo-Pérez, V. M. (2021). Desarrollo de emulsiones de limoneno como productos larvicidas para el control de las larvas de mosquitos Aedes aegypti [Tesis de maestría]. Universidad Santo Tomás, Bucaramanga, Colombiaspa
dc.identifier.instnameinstname:Universidad Santo Tomásspa
dc.identifier.reponamereponame:Repositorio Institucional Universidad Santo Tomásspa
dc.identifier.repourlrepourl:https://repository.usta.edu.cospa
dc.identifier.urihttp://hdl.handle.net/11634/32507
dc.language.isospa
dc.publisherUniversidad Santo Tomásspa
dc.publisher.branchCRAI-USTA Bucaramangaspa
dc.publisher.facultyFacultad de Química Ambientalspa
dc.publisher.programMaestría Ciencias y Tecnologías Ambientalesspa
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dc.rights.accessrightsinfo:eu-repo/semantics/closedAccess
dc.rights.coarhttp://purl.org/coar/access_right/c_14cb
dc.rights.localAcceso cerradospa
dc.subject.keywordAcetylcholinesterasespa
dc.subject.keywordAedes aegyptispa
dc.subject.keywordDanio reriospa
dc.subject.keywordLarvicidal activityspa
dc.subject.keywordR-(+)-limonenespa
dc.subject.keywordS-(-)-limonenespa
dc.subject.keywordEmulsionspa
dc.subject.lembLarvas de insectosspa
dc.subject.lembInsecticidasspa
dc.subject.lembMosquitosspa
dc.subject.lembInsectos vectoresspa
dc.subject.lembMonoterpenosspa
dc.subject.lembEmulsionesspa
dc.subject.proposalAcetilcolinesterasaspa
dc.subject.proposalAcetilcolinesterasaspa
dc.subject.proposalActividad larvicidaspa
dc.subject.proposalAedes aegyptispa
dc.subject.proposalDanio reriospa
dc.subject.proposalAedes aegyptispa
dc.subject.proposalDanio reriospa
dc.subject.proposalR-(+)-limonenospa
dc.subject.proposalS-(-)-limonenospa
dc.subject.proposalR-(+)-limonenospa
dc.subject.proposalActividad larvicidaspa
dc.subject.proposalS-(-)-limonenospa
dc.subject.proposalEmulsiónspa
dc.titleDesarrollo de emulsiones de limoneno como productos larvicidas para el control de las larvas de mosquitos Aedes aegyptispa
dc.typemaster thesis
dc.type.categoryFormación de Recurso Humano para la Ctel: Trabajo de grado de Maestríaspa
dc.type.coarhttp://purl.org/coar/resource_type/c_bdcc
dc.type.coarversionhttp://purl.org/coar/version/c_ab4af688f83e57aa
dc.type.driveinfo:eu-repo/semantics/masterThesis
dc.type.localTesis de maestríaspa
dc.type.versioninfo:eu-repo/semantics/acceptedVersion

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Maestría Ciencias y Tecnologías Ambientales