Determinación de propiedades farmacocinéticas, toxicocinéticas y ADME/Tox de aceites esenciales y compuestos mayoritarios mediante análisis cienciométrico de artículos y patentes

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dc.contributor.advisorCervantes, Martha
dc.contributor.authorEstrada Lagos, Sofía Valentina
dc.contributor.corporatenameUniversidad Santo Tomás
dc.date.accessioned2026-05-08T20:40:21Z
dc.date.available2026-05-08T20:40:21Z
dc.date.issued2026-04-29
dc.descriptionSe recuperó un corpus inicial de 603 artículos y 306 documentos de patente. La producción científica mostró una tendencia creciente, especialmente entre 2021 y 2025, con predominio de Agricultural and Biological Sciences, Chemistry y Biochemistry, Genetics and Molecular Biology. China, India y Arabia Saudita lideraron la producción, mientras que en América Latina la contribución se concentró principalmente en Brasil. La estructura temática del campo se organizó alrededor de bioactividad, caracterización química, modelación computacional y formulación. Discusión y conclusión: El campo evidencia consolidación científica y proyección tecnológica, pero su desarrollo continúa impulsado principalmente por estudios de composición, bioactividad y formulación, mientras que las evaluaciones farmacocinéticas y toxicocinéticas experimentales siguen siendo menos visibles. Esta diferencia constituye la principal brecha del área y, al mismo tiempo, una oportunidad para fortalecer investigaciones orientadas a seguridad, biodisponibilidad y transferencia tecnológica.
dc.description.abstractResearch on essential oils and major compounds has grown steadily; however, knowledge of their pharmacokinetic, toxicokinetic, and ADME/Tox properties remains fragmented, with limited articulation between scientific production and technological development. Objective: To analyze the dynamics, thematic structure, and technological projection of the scientific and inventive activity related to the pharmacokinetic, toxicokinetic, and ADME/Tox properties of essential oils and major compounds. Method: A descriptive, retrospective, and analytical study was conducted using a scientometric and technological surveillance approach, based on records retrieved from Scopus and Lens Patent for the 2016–2026 period. Data processing and analysis were supported by VantagePoint, Bibliometrix, VOSviewer, and Tree of Science. Results: An initial corpus of 603 articles and 306 patent documents was identified. Scientific production showed a growing trend, particularly between 2021 and 2025, with Agricultural and Biological Sciences, Chemistry, and Biochemistry, Genetics and Molecular Biology as the dominant subject areas. China, India, and Saudi Arabia led the scientific output, while Latin American participation was mainly concentrated in Brazil. The thematic structure of the field was organized around bioactivity, chemical characterization, computational modeling, and formulation. Discussion and conclusion: The field shows scientific consolidation and technological projection; however, its development is still mainly driven by studies on composition, bioactivity, and formulation, whereas experimental pharmacokinetic and toxicokinetic evaluations remain less visible. This gap represents the main limitation of the field and, at the same time, an opportunity to strengthen research focused on safety, bioavailability, and technological transfer.
dc.description.degreelevelPregradospa
dc.description.degreenameIngeniero Ambientalspa
dc.description.domainhttps://www.ustabuca.edu.co/
dc.format.mimetypeapplication/pdf
dc.identifier.citationEstrada Lagos, S. V. (2026) Determinación de propiedades farmacocinéticas, toxicocinéticas y ADME/Tox de aceites esenciales y compuestos mayoritarios mediante análisis cienciométrico de artículos y patentes [Trabajo de pregrado] Universidad Santo Tomás, Bucaramanga, Colombia
dc.identifier.instnameinstname:Universidad Santo Tomásspa
dc.identifier.reponamereponame:Repositorio Institucional Universidad Santo Tomásspa
dc.identifier.repourlrepourl:https://repository.usta.edu.cospa
dc.identifier.urihttp://hdl.handle.net/11634/72354
dc.language.isospa
dc.publisherUniversidad Santo Tomásspa
dc.publisher.branchCRAI-USTA Bucaramanga
dc.publisher.facultyFacultad de Ingeniería Ambientalspa
dc.publisher.programPregrado de Ingeniería Ambientalspa
dc.relation.referencesApi, A. M., Belmonte, F., Belsito, D., Biserta, S., Botelho, D., Bruze, M., Burton, G. A., Buschmann, J., Cancellieri, M. A., Dagli, M. L. Z., Date, M., Dekant, W., Deodhar, C., Fryer, A. D., Gadhia, S., Jones, L., Joshi, K., Lapczynski, A., Liebler, D. C., … Tsang, S. (2020). RIFM fragrance ingredient safety assessment, myrcene, CAS Registry Number 123-35-3. Food and Chemical Toxicology, 144(Suppl. 1), 111631. https://doi.org/10.1016/j.fct.2020.111631
dc.relation.referencesApi, A. M., Belmonte, F., Belsito, D., Biserta, S., Botelho, D., Bruze, M., Burton, G. A., Buschmann, J., Cancellieri, M. A., Dagli, M. L. Z., Date, M., Dekant, W., Deodhar, C., Fryer, A. D., Gadhia, S., Jones, L., Joshi, K., Lapczynski, A., Liebler, D. C., … Tsang, S. (2020). RIFM fragrance ingredient safety assessment, myrcene, CAS Registry Number 123-35-3. Food and Chemical Toxicology, 144(Suppl. 1), 111631. https://doi.org/10.1016/j.fct.2020.111631
dc.relation.referencesApi, A. M., Belsito, D., Biserta, S., Botelho, D., Bruze, M., Burton, G. A., Buschmann, J., Cancellieri, M. A., Dagli, M. L. Z., Date, M., Dekant, W., Deodhar, C., Fryer, A. D., Gadhia, S., Jones, L., Joshi, K., Lapczynski, A., Liebler, D. C., O’Brien, D., … Tsang, S. (2021). RIFM fragrance ingredient safety assessment, citronellal, CAS Registry Number 106-23-0. Food and Chemical Toxicology, 149(Suppl. 1), 111991. https://doi.org/10.1016/j.fct.2021.111991
dc.relation.referencesApi, A. M., Belsito, D., Botelho, D., Bruze, M., Burton, G. A., Buschmann, J., Cancellieri, M. A., Dagli, M. L. Z., Date, M., Dekant, W., Deodhar, C., Fryer, A. D., Jones, L., Joshi, K., Lapczynski, A., Liebler, D. C., O’Brien, D., Penning, T. M., Ritacco, G., … Tsang, S. (2022). RIFM fragrance ingredient safety assessment, anethole (isomer unspecified), CAS Registry Number 104-46-1. Food and Chemical Toxicology, 159(Suppl. 1), 112645. https://doi.org/10.1016/j.fct.2021.112645
dc.relation.referencesAtkins, P., & de Paula, J. (2014). Physical chemistry. Oxford University Press.
dc.relation.referencesAwad, M., Hassan, N. N., Alfuhaid, N. A., Amer, A., Salem, M. Z., Fónagy, A., & Moustafa, M. A. (2024). Insecticidal and biochemical impacts with molecular docking analysis of three essential oils against Spodoptera littoralis (Lepidoptera: Noctuidae). Crop Protection, 180, 106659.
dc.relation.referencesAwasthi, A., Soni, S. K., Ahmad, I., & Muthukumar, M. (2025). Microbial synergy promotes palmarosa plant development and essential oil content under organic field condition. Russian Journal of Plant Physiology, 72(4).
dc.relation.referencesBakkali, F., Averbeck, S., Averbeck, D., & Idaomar, M. (2008). Biological effects of essential oils. Food and Chemical Toxicology, 46(2), 446–475.
dc.relation.referencesBickers, D., Calow, P., Greim, H., Hanifin, J. M., Rogers, A. E., Saurat, J. H., Sipes, I. G., Smith, R. L., & Tagami, H. (2003). A toxicologic and dermatologic assessment of linalool and related esters when used as fragrance ingredients. Food and Chemical Toxicology, 41(7), 919–942. https://doi.org/10.1016/S0278-6915(03)00016-4
dc.relation.referencesBreitmaier, E. (2006). Terpenes: Flavors, fragrances, pharmaca, pheromones. Wiley-VCH.
dc.relation.referencesBurt, S. (2004). Essential oils: Their antibacterial properties and potential applications. International Journal of Food Microbiology, 94(3), 223–253.
dc.relation.referencesCasado Villaverde, I. (2018). Optimización de la extracción de aceites esenciales por destilación en corriente de vapor [Trabajo de fin de grado, Universidad Politécnica de Madrid]. Archivo Digital UPM. https://oa.upm.es/49669/
dc.relation.referencesChaieb, K., Hajlaoui, H., Zmantar, T., et al. (2007). The chemical composition and biological activity of clove essential oil. Phytotherapy Research, 21(6), 501–506.
dc.relation.referencesChen, Z., Tang, Y., Lü, Z., Meng, X., Liang, Q., & Feng, J. (2022). Citronella oil nanoemulsion: Formulation, characterization, antibacterial activity, and cytotoxicity. Acta Physico-Chimica Sinica, 38(12), 2205053. https://doi.org/10.3866/PKU.WHXB202205053
dc.relation.referencesCobo, M. J., López-Herrera, A. G., Herrera-Viedma, E., & Herrera, F. (2011). Science mapping software tools: Review. Journal of the American Society for Information Science and Technology, 62(7), 1382–1402.
dc.relation.referencesCrozier, A., Clifford, M. N., & Ashihara, H. (2006). Plant secondary metabolites: Occurrence, structure and role in the human diet. Blackwell Publishing.
dc.relation.referencesCutillas Gomariz, A. B. (2017). Metabolómica de aceites esenciales de mejoranas, romeros y salvias con aplicaciones biotecnológicas [Tesis doctoral, Universidad de Murcia]. Dialnet. https://dialnet.unirioja.es/servlet/tesis?codigo=155059
dc.relation.referencesDe Vincenzi, M., Silano, M., Maialetti, F., & Scazzocchio, B. (2000). Constituents of aromatic plants: II. Estragole. Fitoterapia, 71(6), 725–729. https://doi.org/10.1016/S0367-326X(00)00153-2
dc.relation.referencesde Sousa, D. P., Damasceno, R. O. S., Amorati, R., et al. (2023). Essential oils: Chemistry and pharmacological activities. Biomolecules, 13(7), 1144. https://doi.org/10.3390/biom13071144
dc.relation.referencesDiliberto, J. J., & Birnbaum, L. S. (1990). Metabolism of citral, an alpha,beta-unsaturated aldehyde, in male F344 rats. Drug Metabolism and Disposition, 18(6), 866–875.
dc.relation.referencesDiliberto, J. J., Usha, G., & Birnbaum, L. S. (1988). Disposition of citral in male Fischer rats. Drug Metabolism and Disposition, 16(5), 721–727.
dc.relation.referencesDonthu, N., Kumar, S., Mukherjee, D., Pandey, N., & Lim, W. M. (2021). How to conduct a bibliometric analysis: An overview and guidelines. Journal of Business Research, 133, 285–296.
dc.relation.referencesDrugs.com. (2025, August 13). Anise uses, benefits & dosage. https://www.drugs.com/npp/anise.html
dc.relation.referencesDubey, V. S., Bhalla, R., & Luthra, R. (2003). An overview of the non-mevalonate pathway. Journal of Biosciences, 28(5), 637–646.
dc.relation.referencesEaton, D. L., & Klaassen, C. D. (2001). Principles of toxicology. En Casarett & Doull's toxicology. McGraw-Hill.
dc.relation.referencesElgharib, I. M., Abdelhamid, F. M., Elshopakey, G. E., Sembawa, H., Albukhari, T. A., Filimban, W. A., Bagadood, R. M., El-Boshy, M. E., & Risha, E. F. (2025). Therapeutic potential of clove oil in mitigating cadmium-induced hepatorenal toxicity through antioxidant, anti-inflammatory, and antiapoptotic mechanisms. Pharmaceuticals, 18(1), 94.
dc.relation.referencesEuropean Medicines Agency. (2013). Assessment report on Pimpinella anisum L., fructus.
dc.relation.referencesFischer, I. U., von Unruh, G. E., & Dengler, H. J. (1990). The metabolism of eugenol in man. Xenobiotica, 20(2), 209–222. https://doi.org/10.3109/00498259009047156
dc.relation.referencesGonzález de C., N., & Usubillaga, A. (2007). Composición del aceite esencial de Origanum majorana L. extraído por diferentes técnicas y su actividad biológica. Revista de la Facultad de Agronomía (LUZ), 24(4), 619–634. https://ve.scielo.org/scielo.php?pid=S0378-78182007000400008&script=sci_arttext
dc.relation.referencesGoswami, A. K., Sarma, A., Ahmed, S., & Das, B. K. (2025). Linalool in chronic diseases: A comprehensive review of its metabolism, pharmacological mechanisms, and drug delivery strategies. Fitoterapia, 186, 106754. https://doi.org/10.1016/j.fitote.2025.106754
dc.relation.referencesHood, W. W., & Wilson, C. S. (2001). The literature of bibliometrics, scientometrics, and informetrics. Scientometrics, 52(2), 291–314.
dc.relation.referencesHuang, S., Dong, R., Xu, G., Liu, J., et al. (2020). Synthesis, characterization, and in vivo evaluation of desmethyl anethole trithione phosphate prodrug for ameliorating cerebral ischemia-reperfusion injury in rats. ACS Omega, 5(9), 4595–4602. https://doi.org/10.1021/acsomega.9b04129
dc.relation.referencesINESALUD. (2025, septiembre 10). Beneficios del anís estrellado para la salud. INESALUD. https://www.inesalud.com/actualidad-sanitaria/investigacion/plantas-medicinales
dc.relation.referencesLin, J. H., & Lu, A. Y. H. (1997). Role of pharmacokinetics and metabolism in drug discovery and development. Pharmacological Reviews, 49(4), 403–449.
dc.relation.referencesLetizia, C. S., Cocchiara, J., Lalko, J., & Api, A. M. (2003). Fragrance material review on linalool. Food and Chemical Toxicology, 41(7), 943–964. https://doi.org/10.1016/S0278-6915(03)00015-2
dc.relation.referencesLi, Y., Bian, B., Tang, R., Zhang, K., Li, F., Li, P., Li, L., Zhang, M., & Zhang, H. (2024). Characterization of a clove essential oil slow-release microencapsulated composite film and its preservation effects on blueberry. ACS Omega, 9(11), 12643–12656. https://doi.org/10.1021/acsomega.3c07169
dc.relation.referencesLi, Y., Zhang, J., Zhang, W., Jiang, J., Wang, Y., Yang, F., & Xia, W. (2025). Citral: Bioactivity, metabolism, delivery systems, and food applications. Comprehensive Reviews in Food Science and Food Safety. Advance online publication. https://doi.org/10.1111/1541-4337.70168
dc.relation.referencesMEDINA, M. m. a. [FdUCUB1.1](2011). Aceites esenciales: usos, composiciones químicas y actividades biológicas. Universidad Nacional Autónoma de México.
dc.relation.referencesMoed, H. F. (2005). Citation analysis in research evaluation. Springer.
dc.relation.referencesMontgomery, D. C., Jennings, C. L., & Kulahci, M. (2015). Introduction to time series analysis and forecasting. Wiley.
dc.relation.referencesNerio, L. S., Olivero-Verbel, J., & Stashenko, E. (2010). Repellent activity of essential oils. Bioresource Technology, 101(1), 372–378.
dc.relation.referencesNelson, D. L., & Cox, M. M. (2017). Lehninger principles of biochemistry. W. H. Freeman.
dc.relation.referencesOECD. (2001). Guidelines for the testing of chemicals: Acute oral toxicity. Organisation for Economic Co-operation and Development.
dc.relation.referencesOlarte Cetina, C. J. (2018). Evaluación de la actividad antioxidante de extractos de Cymbopogon citratus en dos estados fenológicos sometidos a radiación UV-B [Trabajo de grado, Universidad Nacional Abierta y a Distancia]. Repositorio Institucional UNAD. https://repository.unad.edu.co/bitstream/handle/10596/19478/1073231930.pdf
dc.relation.referencesPrabawati, S. Y., Triatmaja, K., & Widiakongko, P. D. (2025). Molecular docking study of eugenol and its derivatives as potential anti-ischemia agents for angiotensin converting enzyme (ACE) inhibition. Indonesian Journal of Chemistry, 25(3), 929–942. https://doi.org/10.22146/ijc.101791
dc.relation.referencesPu, Z., Yin, C., Luo, T., Shi, J., & Dai, M. (2026). Preparation, characterization, and antibacterial activity of geraniol and citral co-encapsulated liposomes: In vitro and in vivo studies. Chemistry & Biodiversity, 23(3), e03471. https://doi.org/10.1002/cbdv.202503471
dc.relation.referencesRang, H. P., Dale, M. M., Ritter, J. M., & Flower, R. J. (2016). Rang and Dale’s pharmacology. Elsevier.
dc.relation.referencesRowland, M., & Tozer, T. N. (2011). Clinical pharmacokinetics and pharmacodynamics. Wolters Kluwer.
dc.relation.referencesShah, G., Shri, R., Panchal, V., Sharma, N., Singh, B., & Mann, A. S. (2011). Scientific basis for the therapeutic use of Cymbopogon citratus. Journal of Advanced Pharmaceutical Technology & Research, 2(1), 3–8.
dc.relation.referencesShargel, L., Wu-Pong, S., & Yu, A. B. C. (2012). Applied biopharmaceutics & pharmacokinetics. McGraw-Hill.
dc.relation.referencesTang, G., Zhou, Z., Zhang, X., et al. (2023). Fabrication of supramolecular self-assembly of the Schiff base complex for improving bioavailability of aldehyde-containing plant essential oil. Chemical Engineering Journal, 471, 144471. https://doi.org/10.1016/j.cej.2023.144471
dc.relation.referencesTaiz, L., Zeiger, E., Møller, I. M., & Murphy, A. (2015). Plant physiology and development. Sinauer Associates.
dc.relation.referencesvan de Waterbeemd, H., & Gifford, E. (2003). ADMET in silico modelling: Towards prediction paradise? Nature Reviews Drug Discovery, 2(3), 192–204. World Health Organization. (2007). WHO monographs on selected medicinal plants (Vol. 3).
dc.rightsAttribution-NoDerivs 2.5 Colombiaen
dc.rights.accessrightsinfo:eu-repo/semantics/openAccess
dc.rights.coarhttp://purl.org/coar/access_right/c_abf2
dc.rights.localAbierto (Texto Completo)spa
dc.rights.urihttp://creativecommons.org/licenses/by-nd/2.5/co/
dc.subject.keywordessential oils, ADME/Tox, pharmacokinetics, toxicokinetics, scientometrics
dc.subject.proposalaceites esenciales, ADME/Tox, farmacocinética, toxicocinética, cienciometría
dc.titleDeterminación de propiedades farmacocinéticas, toxicocinéticas y ADME/Tox de aceites esenciales y compuestos mayoritarios mediante análisis cienciométrico de artículos y patentes
dc.typebachelor thesis
dc.type.categoryApropiación Social y Circulación del Conocimiento: Consultoría científico-tecnológica
dc.type.coarhttp://purl.org/coar/resource_type/c_7a1f
dc.type.coarversionhttp://purl.org/coar/version/c_ab4af688f83e57aa
dc.type.driveinfo:eu-repo/semantics/bachelorThesis
dc.type.localTrabajo de Gradospa
dc.type.versioninfo:eu-repo/semantics/acceptedVersion

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