Síntesis, caracterización y estudio de la actividad larvicida de nuevos 2-[bencil(aril)amino]acetonitrilos

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dc.contributor.advisorVargas Mendez, Leonor Yamilespa
dc.contributor.authorAlvarez Angarita, Yelicsa Dayanaspa
dc.coverage.campusCRAI-USTA Bucaramangaspa
dc.date.accessioned2020-02-04T13:57:49Zspa
dc.date.available2020-02-04T13:57:49Zspa
dc.date.issued2020-02-02spa
dc.descriptionEl Aedes aegypti (Díptera: Culicidae) es una de las especies de zancudos que trasmiten enfermedades virales, como dengue, fiebre amarilla, zika, chikungunya y mayaro, entre otras. La disminución en el contagio de estas enfermedades está basada en el control de los vectores. Dentro de ellos se encuentra el control químico, que es uno de los métodos más empleados, en este método se utilizan insecticidas sintéticos como los organofosforados; sin embargo, diversas poblaciones de dichos mosquitos alrededor del mundo han mostrado resistencia a estos, amenazando el control del vector. La continua necesidad de sintetizar y explorar nuevas moléculas bioactivas como larvicidas hizo que en el presente trabajo de grado se prepararan y estudiaran nuevos derivados de α-aminonitrilos Los α-aminonitrilos evaluados como larvicidas son nuevas alternativas para el control del vector debido a que son altamente activos CL50 < 50 ppm frente a larvas en tercer instar del zancudo Aedes aegypti, cepa Piedecuesta. De los diez compuestos evaluados, la 3,4-dicloro-N-(-4-clorobencil)anilina presentó la mejor actividad larvicida con una CL50 de 3.16 ppm. Los nuevos compuestos sintetizados pueden ser útiles para desarrollar formulaciones que puedan usarse en el control de mosquitos transmisores de enfermedades. Palabras clave: Aedes aegypti, α-aminonitrilos, actividad larvicida.spa
dc.description.abstractAedes aegypti (Dipteran: Culicidae) is one of the species of mosquitoes that transmit viral diseases, such as dengue, yellow fever, zika, chikungunya and mayaro, among others. The decrease in the spread of these diseases is based on vector control. Among them is the chemical control, which is one of the most used methods, in this method synthetic insecticides such as organophosphates are used; however, various populations of these mosquitoes around the world have shown resistance to these, threatening vector control. The continuing need to synthesize and explore new bioactive molecules such as larvicides meant that in the present dissertation project new α-aminonitrile derivatives were prepared and studied The α-aminonitriles evaluated as larvicides are new alternatives for vector control because LC50 <50 ppm are highly active against third instar larvae of the Aedes aegypti mosquito, Piedecuesta strain. Of the ten compounds evaluated, 3,4-dichloro-N - (- 4-chlorobenzyl) aniline had the best larvicidal activity with an LC50 of 3.16 ppm. The new synthesized compounds may be useful for developing formulations that can be used in the control of disease-transmitting mosquitoes. Keywords: Aedes aegypti, α-aminonitriles, larvicidal activity.spa
dc.description.degreelevelPregradospa
dc.description.degreenameQuímico Ambientalspa
dc.description.domainhttps://www.ustabuca.edu.co/spa
dc.format.mimetypeapplication/pdfspa
dc.identifier.citationAlvarez A, Y., Síntesis, caracterización y estudio de la actividad larvicida de nuevos 2-[bencil(aril)amino]acetonitrilos (2020).spa
dc.identifier.instnameinstname:Universidad Santo Tomásspa
dc.identifier.reponamereponame:Repositorio Institucional Universidad Santo Tomásspa
dc.identifier.repourlrepourl:https://repository.usta.edu.cospa
dc.identifier.urihttp://hdl.handle.net/11634/21390
dc.language.isospaspa
dc.publisherUniversidad Santo Tomásspa
dc.publisher.facultyFacultad de Química Ambientalspa
dc.publisher.programPregrado Química Ambientalspa
dc.relation.referencesAlinezhad, H., Yavari, H., & Salehian, F. (2015). Recent advances in reductive amination. Catalysis and its applications. Current Organic Chemistry 19(11), 1021-1049.spa
dc.relation.referencesAnez, G., Chancey, C., Grinev, A., & Rios, M. (2012). Dengue virus and other arboviruses: A global view of risks. ISBT Science Series, 7(1), 274-282. doi: 10.1111/j.1751-2824.2012. 01602.xspa
dc.relation.referencesAraya, R. L., Carazo, E. R., & Cartin, V. M. (2005). Diagnóstico del uso de insecticidas utilizados contra Bemisia tabaci (Gennadius) en tomate y Chile en Costa Rica. Manejo Integrado de Plagas y Agroecología 75(1), 68-76.spa
dc.relation.referencesAttar, N. (2016). ZIKA virus circulates in new regions. Nature Reviews Microbiology, 14(2), 62-62. doi: org/10.1038/nrmicro.2015.28.spa
dc.relation.referencesBaker-Austin, C., Trinanes, J.A., Taylor, N.G.H., Hartnell, R., Siitonen, A., & Martinez-Urtaza, J. (2013). Emerging Vibrio risk at high latitudes in response to ocean warming. Nature Climate Change 5(3), 73-77- doi: org/10.1038/nclimate1628.spa
dc.relation.referencesBisset, J. A. (2002). Uso correcto de insecticidas: control de la resistencia. Medicina Tropical 54(3), 202-219.spa
dc.relation.referencesBisset, Lazcano., J. A., Rodríguez, M. M., San Martin, J. L., Romero, J. E., & Montoya, R. (2009). Evaluación de la resistencia a insecticidas de una cepa de Aedes aegypti de el salvador. Pan American Health Organization, 26(3), 229-234.spa
dc.relation.referencesBotello, A. V; Von Osten J, R., Gold-Bouchot. G., & Agraz-Hernandez, C. (2005). Golfo de México: contaminación e impacto ambiental: diagnóstico y tendencias. (Eds.), 2da ed.,Universidad Autonoma de Campeche, Universidad Nacional Autónoma de México, Instituto Nacional de Ecología. Campeche México pp. 261-268.spa
dc.relation.referencesBraga, I. A., Lima, Pereira, J. B., Sidinei da, S. S., & Valle, D. (2004). Aedes aegypti resistance to temephos during 2001 in several municipalities in the states of Rio de Janeiro, Sergipe, and Alagoas, Brazil. Memórias do Instituto Oswaldo Cruz 99(2), 199-203. doi.org/10.1590/S0074-02762004000200015spa
dc.relation.referencesBrown, A.W. (1986). Insecticide resistance in mosquitoes: A pragmatic review. Journal of the American Mosquito Control Association 2(2), 123-140.spa
dc.relation.referencesBurge, C.A., Friedman, C.S., Froelich, B., Ford, S.E., Harvell, C.D., Hershberger, P.K., Hofmann, E.E., Mark-Eakin, C., Prager, K.C., Petes, L.E., Weil, E., & Willis, B. L. (2014). Climate change influences on marine infectious diseases: implications for management and society. Annual Review of Marine Science 6, 249-277. doi: 10.1146/annurev-marine-010213-135029.spa
dc.relation.referencesByun, E., Hong, B., De Castro, K. A., Lim, M., & Hakjune. Rhee., (2007). One-pot reductive mono-N-alkylation of aniline and nitroarene derivatives using aldehydes. The Journal of Organic Chemistry 72(25), 9815-9817. doi: org/10.1021/jo701503q.spa
dc.relation.referencesCáceres, L., Rovira, J., García, A., & Torres, R. (2011).) Determinación de la resistencia a insecticidas organofosforados, carbamatos y piretroides en tres poblaciones de Anopheles Albimanus (Díptera: Culicidae) de Panamá. Biomedica 31(3), 419-427. doi: org/10.7705/biomedica.v31i3.388spa
dc.relation.referencesCahyo Mulyatno K., Yamanaka, A., Ngadino., & Konish. (2012). Resistencia de Aedes aegypti (L.) larvae a temephos en Surabaya, Indonesia. The Southeast Asian journal of tropical medicine and public health 43 (1); 29-33spa
dc.relation.referencesCao-Lormeau, V. M., Roche, C., Teissier, A., Robin, E., Berry, A. L., Mallet, H. P., Sall, A. A; & Musso, D. (2014). Zika virus, french polynesia, south pacific, 2013. Emerging Infectious Diseases, 20(6), 1085-1086. doi: 10.3201/eid2006.140138.spa
dc.relation.referencesCarey, F., a (2006), Química orgánica. (6ta ed., pp. 639-640). McGraw-Hill InterAmericanaspa
dc.relation.referencesCarreño Otero., A, L; Vargas Méndez, L, Y., Duque, L., J. E., & Kouznetzov, V. V., & (2014). Desing, synthesis, acetylcholinesterase inhibition and larvicidal activity of girgensohnine analogs on Aedes aegypti, vector of dengue. European Journal of Medicinal Chemistry, 78(1), 392-400. doi: 10.1016/j.ejmech.2014.03.067.spa
dc.relation.referencesCenters for Disease Control and Prevention. (2016). Flaviviridae. Recuperado el 30 de junio de 2018, de la fuente: https://www.cdc.gov/vhf/virus-families/flaviviridae.html.spa
dc.relation.referencesCharpentier, A., Menozzi, P., Marcel, V., Villatte, F & Fournier, D. (2000). A method to estimate acetylcholinesterase-active sites and turnover in insects. Analytical Biochemistry 285(1), 76-81. doi:10.1006/abio.2000.4738.spa
dc.relation.referencesChaudhry, M., Prabhu-Dass, J.F., Selvakumar, D., Kumar, N.S. (2013). In-silico study of acetylcholinesterase inhibition by organophosphate pesticides. International Journal of Pharma and Bio Sciences 4(3), 788-802.spa
dc.relation.referencesChen, L. H., Hamer, D. H. (2016). Zika virus: Rapid spread in the western hemisphere. Annals of Internal Medicine 164(9), 613-615. doi: 10.7326/M16-0150.spa
dc.relation.referencesColleen A. B., Mark, E. C., Carolyn, S. Friedman., Brett, Froelich., Hershberger, P. K., Hofmann, E. E., Peters, L. E., Prager, K. C., Weil, E., Bette, L., Willis, S. E., Ford, and Drew Harvell. (2014). Climate change influences on marine infectious diseases: implications for management and society. Annual Review of Marine Science 6, 249-277. doi: 10.1146/annurev-marine-010213-135029spa
dc.relation.referencesCruz, S., Cifuentes, D., Hurtado, N., & Roman, M. (2016). Solvent-free microwave synthesis of pyridazin-3(2H)-ones. Información Tecnológica 27(5), 57-62. doi: 10.4067/S0718-07642016000500007spa
dc.relation.referencesCuadros, J., Carreño, A. L., Kouznetsov, V. V., & Duque, J. E. (2017). Acción insecticida de análogos de girgensohnina sintéticos y aceites esenciales en Rhodnius prolixus (Hemiptera: Reduviidae). Biomédica 37(2), 50,58 doi.org/10.7705/biomedica.v37i0.3379spa
dc.relation.referencesDiagne, C. T., Diallo, D., Faye, O., Ba, Y., Faye, O., Gaye, A., Dia, I., Ibrahima., Faye, O.,Weaver, S. C., Sall A. A., & Diallo, M. (2015). Potential of selected Senegalese Aedes spp. mosquitoes (Diptera: Culicidae) to transmit Zika virus. BMC Infectious Diseases, 15(1), 2-6. doi:10.1186/s12879-015-1231-2spa
dc.relation.referencesDias, C.N. & Moraes, D.F.C. (2014). Essential oils and their compounds as Aedes aegypti L. (Diptera: Culicidae) Larvicides. Parasitology Research 113(2), doi.org/10.1007/s00436-013-3687-6spa
dc.relation.referencesDick, G., Kitchen, S., Haddow, A. (1952). Zika Virus I. isolations and serological specificity. Transactions of the Royal Society of Tropical Medicine and Hygiene 46(5), 509-520. doi: 10.1016/0035-9203(52)90042-4spa
dc.relation.referencesDieter, E., & Shilvock, J. Some recent applications α-amino nitrile; Chemical Society Review 2000(5), 359-373. doi: 10.1039/A908290Espa
dc.relation.referencesDitsuwan, T., Liabsuetrakul, T., Ditsuwan, V., Thammapalo, S. (2012). Cost of standard indoor ultra-low-volume space spraying as a method to control adult dengue vectors. Tropical Medicine & International Health 17(6), 767- 740. doi: 10.1111/j.1365-3156.2012.02997 doi: 10.2174/1385272819666150311233021.spa
dc.relation.referencesDuffield, A. M.; Budzikiewicz, H.; Williams, D. H.; Djerassi, C. (1965). Mass spectrometry in structural and stereochemical problems. LXIV.1 A study of the fragmentation processes of some cyclic amine. J. Am. Chem. Soc. 87, p.810-816.spa
dc.relation.referencesDuffy, M., Chen, T., Hancock, W., Powers, A., Kool, J., Lanciotti, R., Guillaumot, L., Griggs, A. M., Lambert, A. J., Laven, J., Kosoy, O., Panella, A, Biggerstaff B. J., Fischer, M., & Hayes E. B. (2009). Zika virus outbreak on yap island, Federated States of Micronesia. The New England Journal of Medicine, 24(350), 2536-2543. doi: 10.1056/NEJMoa0805715.spa
dc.relation.referencesDuthaler, R. (1994). Recent developments in the stereoselective synthesis of α-aminonitriles. Tetrahedron 50(6), 1539-1650. doi: 10.1016/j.tet.2006.08.105spa
dc.relation.referencesEnders, D. (2000). Reactions for Functional Group Transformations. (3era ed., pp. 359-373). Jie Jack Li Pfizer Global Research & Development.spa
dc.relation.referencesEsu, E., Horstick, O., Lenhart, A., & Smith L. (2010). Effectiveness of peridomestic space spraying with insecticide on dengue transmission; systematic review. Tropical Medicine & International Health 15(5), 619-631. doi: 10.1111/j.1365-3156.2010.02489.x.spa
dc.relation.referencesEvangelista, I. M. (1998). Plaguicidas: Aspectos ambientales, analíticos y toxicológicos (4ta ed., pp. 275-276) Editorial Castelló de la Plana Publicacions de la Universitart Jaume Ispa
dc.relation.referencesFagbami, A. (1979). Zika virus infections in Nigeria: Virological and seroepidemiological The Journal of Hygiene 83(2), 213-219. doi:10.1017/s00221724000 25997spa
dc.relation.referencesFAO (1993). Estado mundial de la agricultura y la alimentación. Recuperado el 6 de marzo de 2019. http://www.fao.org/3/a-t0800s.pdfspa
dc.relation.referencesFaye, O., Faye, O., De Olivera., Freire, C., Iamarino, A., J., Diallo, M, & Simpson, D. (2014). Molecular evolution of zika virus during its emergence in the 20th century. Plos Neglected Tropical Diseases, 8(1), 2636. doi: org/10.1371/journal.pntd.0002636spa
dc.relation.referencesGaramszegi, L.Z. (2011). Climate change increases the risk of malaria in birds. Global Change Biology 17(5), 1751-1759. doi: org/10.1111/j.1365-2486.2010.02346.spa
dc.relation.referencesGarrett, K., Dobson, A.D.M., Kroschel, J., Natarajan, B., Orlandini, S., Tonnang, H.E., & Valdivia, C. (2013). The effects of climate variability and the color of weather time series on agricultural diseases and pests, and on decisions for their management. Agricultural and Forest Meteorology 170, 216-227. doi: org/10.1016/j.agrformet.2012.04.018spa
dc.relation.referencesGómez, A, V., Biswas, A., Tadini, C, C., Furtado, R, F., Alves, C, R., Cheng, H, N (2019). Use of Natural Deep Eutectic Solvents for Polymerization and Polymer Reactions. Revista de la sociedad Brasileña de Química 30 (4), 717-726. doi: org/10.21577/0103-5053.20190001.spa
dc.relation.referencesGonzález, G. (2013). Resistencia a insecticidas en el mosquito vector del dengue Aedes aegypti (L.) en dos épocas de trasmisión de la enfermedad en Mérida, Yucatán. Tesis doctoral. Universidad Autonoma de Nuevo León. p.132.spa
dc.relation.referencesGregor, J., Dominique, E., Ogusuku, E., & Michael, J. (2008). Uso de insecticidas: contexto y consecuencias ecológicas. Revista Peruana de Medicina Experimental y Salud Publica 25(1), 74-100.spa
dc.relation.referencesGregory, Uso de insecticidas J., Devine1, A., Dominique, E., Ogusuku, E., & Furlong, M. (2008) Uso de insecticidas contexto y consecuencias ecológicas. Revista Peruana de Medicina Experimental y Salud Publica 25(1), u74-100.spa
dc.relation.referencesHarvell, C., Mitchell, C., Ward, J. Altizer, S., Dobson, A., Ostfeld, R., Samuel, M. (2002) Climate warming and disease risks for terrestrial and marine biota. Science 296(5576), 2158-2162. doi: 10.1126/science.1063699spa
dc.relation.referencesHarvell, D., Altizer, S., Cattadori, I.M., Harrington, L., & Weil, E. (2009). Climate change and wildlife diseases: When does the host matter the most. Ecology 90(4), 912-920.spa
dc.relation.referencesHayes, E. (2009). Zika virus outside africa; Emerging Infefctious Diseases, 15(9), 1347-1350. doi: 10.3201/eid1509.090442.spa
dc.relation.referencesHemingway, J., & Ranson, H. Insecticide resistance in insect vectors of human disease. 45(1), 371-391. doi: 10.1146/annurev.ento.45.1.371.spa
dc.relation.referencesHennessey, M., Fischer, M., & Staples, E. (2016). Zika Virus Spreads to New Areas- region of the Americas, May 2015-january 2016. Morbidity and Mortality Weekly Reort (MMWR), 65(3), 55-58. doi: 10.15585/mmwr.mm6503e1.spa
dc.relation.referencesHiggs, s. (2016). Zika virus: Emergence and emergency Vector-Borne and Zoonotic Diseases, 16(2), 75-76. doi: 10.1089/vbz.2016.29001.higspa
dc.relation.referencesIDEAM (2017). Tercera Comunicación Nacional de Colombia: Resumen Ejecutivo: Bogotá. http://documentacion.ideam.gov.co/openbiblio/bvirtual/023732/RESUMEN_EJECUTIVO_ TCNCC_COLOMBIA.pdfspa
dc.relation.referencesInstituto Nacional de Salud (INS). (2018). Semana epidemiológica 22. Recuperado el 23 junio de 2019, de la fuente: https://www.ins.gov.co/buscador-eventos/BoletinEpidemiologico/2018%spa
dc.relation.referencesInstituto Nacional de Salud (INS). (2019-1). Semana epidemiológica 22. Recuperado el 23 junio de 2019, de la fuente: https://www.ins.gov.co/buscador-eventos/BoletinEpidemiologico/ 2019%20Bolet%C3%ADn%20epidemiol%C3%B3gico%20semana%2022.pdf?fbclid=IwAR0k7APrSVioOG0tiYLAQ1Ne4KIx3jjkSkQX48Pjt1dRG7m-YXlKtReQOn4.spa
dc.relation.referencesInstituto Nacional de Salud (INS). (2019-2). Semana epidemiológica 23. Recuperado el 23 junio de 2019, de la fuente https://www.ins.gov.co/buscador-eventos/BoletinEpidemiologico/ 2019%20Boletín%20epidemiológico%20semana%2023.pdfspa
dc.relation.referencesInstituto Nacional del Cáncer de Estados Unidos. (2017). Artralgia. Recuperado el 4 de marzo de la fuente: https://www.cancer.gov/espanol/publicaciones/diccionario?cdrid=455150.spa
dc.relation.referencesIoos, S., Mallet, H., Goffart, I., Cardoso, T., & Herida, M. (2014). Current zika virus epidemiology and recent epidemics. Medicine Et Maladies Infectieuses 44(7), 302-307. doi:10.1016/j.medmal.2014.04.008.spa
dc.relation.referencesJeschke, P., Moriya, K., Lantzsch, R., Seifert, H., Linder, W., Jelich, K., Gohrt, A., Beck, M.E & Etzel, W. (2001). Thiacloprid a new membeer of the chloronicotinyl insecticide (CNI) family. Pflanzenschutz Nachrichten Bayer (English Edition 54(2), 147-160.spa
dc.relation.referencesJirakanjanakit, N., Rongnoparut, P., Saengtharatip, S., Chareonviriyaphap, T., Duchon, S., Bellec, C., & Yoksan, S. (2007). Insecticide susceptible/ resistance status in Aedes (Stegomyia) aegypti and Aedes (Stegomyia) albopictus (Diptera: Culicidae) in Thailand during 2003-2005. Journal of Economic Entomology 100(2), 545-550. doi: 10.1603/0022-0493(2007)100[545:IRSIAS]2.0.CO;2.spa
dc.relation.referencesJones, K., Patel, N., Levy, M., Storeygard, A., Balk, D., Gittleman, J., & Daszak, P. (2008). Global trends in emerging infectious diseases. Nature 451(7181), 990-993. doi: 10.1038/ nature06536.spa
dc.relation.referencesKuno, G. (2007). Research on dengue and dengue-like illness in East Asia and the Western Pacific during the first half of the 20th century. Reviews in Medical Virology 17(5), 327-341. doi:10.1002/rmv.545spa
dc.relation.referencesLazaro, Lazaro, E., & Homs C.E. (2002). Virus Emergentes: La Amenaza Oculta. (1ra ed., pp. 513-602.)spa
dc.relation.referencesLazcano, J., Rodríguez, M., San Martin., J., Romero J., & Montoya R. (2009). Evaluación de la resistencia a insecticidas de una cepa de Aedes aegypti de el salvador. Revista Panamericana De Salud Pública, 26(3), 229-234.spa
dc.relation.referencesLiu, N. (2015). Insecticide resistance in mosquitoes: Impact, mechanisms, and research directions. Annual Review of Entomology 60(1), 537-559. doi: 10.1146/annurev-ento-010814-020828spa
dc.relation.referencesLobaina, C, A., Tamayo R, O., Zamora Y., & Castle, Y (2005). Obtención de bases de schiff por condensación del ohidroxibenzaldehido con anilina y p-derivados. Revista cubana de Química XVll (2) 33-43.spa
dc.relation.referencesLópez, S., Garrido, F., & Hernández M. (2000). Desarrollo histórico de la epidemiologia: formación como disciplina científica. Salud Pública de México 42(2), 133-137.spa
dc.relation.referencesMaestre S, R., Rey, V. G., Salas, A. J., Vergara, S. C., Santacoloma, V. I., Goenaga, S. O., & Carrasquilla, F. M. C. (2009). Susceptibilidad de Aedes aegypti (Diptera: Culicidae) a temefos en Atlántico-Colombia. Revista Colombiana de Entomología 35(2) 202-205.spa
dc.relation.referencesMartins, J. A., Lins, R., M., M., A., Gerlind, J., Linss, B., Peixoto, A. A., & Valle, D (2009). Voltage-gated sodium channel polymorphism and metabolic resistance in pyrethroid-resistant Aedes aegypti from Brazil. The American Journal of Tropical Medicine and Hygiene 81(1), 108-115. doi: org/10.4269/ajtmh.2009.81.108.spa
dc.relation.referencesMassoulie, J; Pezzementi, L., Bon, S., Krejci, E., & Vallette, F.M. (1993). Molecular and cellular biology of cholinesterases. Progress in Neurobiology 41(1), 31-91.spa
dc.relation.referencesMorita, M., Ueda, T., Yoneda, T., Koyanagi, T., & Haga, T. (2007). Flonicamid, a novel insecticide with a rapid inhibitory effect on aphid feeding. Pest Management Science 63(10), 969-973. doi: 10.1002/ps.1423spa
dc.relation.referencesMorrison, T.R., Boyd. N.R. (1990). Química Orgánica. (5ta ed., pp. 934-942). Editorial Addison-Wesley Iberoamericanaspa
dc.relation.referencesMusso, D. (2015). Zika virus transmission from French Polynesia to Brazil. Emerging Infectious Diseases 21(10), 1887-1887. doi:10.3201/eid2110.151125spa
dc.relation.referencesMutero, A., Pralavorio, M., Bride, J.M., Fournier, D. (1994). Resistance associated point mutations in insecticide-insensitive acetylcholinesterase. Proceedings of the National Academy of Sciences 91(13), 5922-5926. doi: 10.1073/pnas.91.13.5922.spa
dc.relation.referencesNezhad, A.K., Divar, M., & Panahi, F. (2013). Synthesis of α-aminonitriles with benzimidazolic and theophyllinic backbones using the Strecker reaction. The Journal of Organic Chemistry 78(21), 10902-10908. doi: org/10.1021/jo401890g.spa
dc.relation.referencesNoisakran, S.; Chokephaibulkit, K.; Songprakhon, P.; Onlamoon, N.; Hsiao, H-M.; Villinger, F.; Ansari, A.; Perng, G.C. (2009). A re-evaluation of the mechanisms leading to dengue hemorrhagic fever. Annals of the New York Academy of Science 1171, E24-E35. doi: 10.1111/j.1749-6632.2009.05050.spa
dc.relation.referencesOcampo, C., Brogdon, W., Salazar, M., Mina, N., & McAllister, J. (2011). Insecticide resistance status of aedes aegypti in 10 localities in Colombia. Acta Tropica, 118(1), 37-44. doi: 10.1016/j.actatropica.2011.01.007.spa
dc.relation.referencesOrganización Mundial de la Salud (2018). Dengue y dengue severo. Recuperado el 4 de marzo de 2019. https://www.who.int/es/news-room/fact-sheets/detail/dengue-and-severe-dengue.spa
dc.relation.referencesOrganización Mundial de la Salud (OMS), (2016). Síndrome de Guillain-Barrré Recuperado el 9 abril de 2019,https://www.who.int/es/newsroom/factsheets/detail/guillainbarr%C3%A9syndrome?fbclid=IwAR1HxBFcigThPONqIOlgx6ZSpoF5IUCsShiRdUo-4LYY3PFAqh8MuUherJAspa
dc.relation.referencesOrganización Mundial de la Salud (OMS), (2017-1). Lucha contra el dengue. Recuperado el 4 De marzo de 2019, de la fuente: https://www.who.int/denguecontrol/mosquito/es/spa
dc.relation.referencesOrganización Mundial de la Salud (OMS), (2017-2). Enfermedades trasmitidas por vectores. Recuperado el 5 de marzo de 2019, de la fuente https://www.who.int/es/news-room/fact-sheets/detail/vector-borne-diseasesspa
dc.relation.referencesOrganización Mundial de la Salud (OMS), (2019). Dengue y dengue grave. Recuperado el 9 marzo de 2019, de la fuente: https://www.who.int/es/newsroom/factsheets/detail/denguan dseveredengue?fbclid=IwAR3gXjr9Bgki8MQDevxMKEpVvzSInRchMUXpq12gdqDQINQLB9mjJmv-0LAspa
dc.relation.referencesOrganización Mundial de la Salud, (OMS). (2011). Global insecticide use for vector-borne disease control: A 10-Year assessment (2000-2009). Consultado el 29 de agosto de 2018, de la fuenta http://apps.who.int/iris/bitstream/10665/44670/1/9789241502153spa
dc.relation.referencesOrganización Mundial de la Salud, (OMS). (2012). Dengue y dengue hemorrágico. Recuperado el 7 marzo de 2019. http://apps.who.int/mediacentre/factsheets/fs387/es/index2.htmlspa
dc.relation.referencesPinkus, R. (2010). El hombre y los artrópodos: Un vínculo inalienable. Universidad Nacional Autónoma de México, 5(2), 81-100.spa
dc.relation.referencesPuc, V., Herrera, J., Carmona, C., Mendoza, A., Medina, A., Chablé, J., Arredondo, J., Suárez, A., & Manrique, P. (2016). Effectiveness of commercial repellents against Aedes aegypti (L.) in Yucatan, México. Salud Publica de México 58(4), 472-475. doi:org/10.21149/spm.v58i4.8030spa
dc.relation.referencesRendón, M. A. (2010). El hombre y los artrópodos: un vínculo inalienable. Revista Península 5(2), 81-100spa
dc.relation.referencesRodríguez, A., M., Prieto, P, de la Hoz A., Diaz Ortiz, A., Martin, D, R & Garcia, J, I. (2015). Influence of polarity and activaton energy in microwave-assisted organic synthesis (MAOS). ChemistryOpen 4(3), 308-317 doi: 10.1002/open.201402123.spa
dc.relation.referencesRodríguez, A., Suárez, S., & Palacio, D. (2014). Efectos de los plaguicidas sobre el ambiente y la salud. Revista Cubana de Higiene y Epidemiología 52(3), 1561-3003.spa
dc.relation.referencesRosenberg, R. (2015). Detecting the emergence of novel, zoonotic viruses pathogenic to humans. Cellular and Molecular Life Sciences 72(6), 1115-1125. doi: 10.1007/s00018-014-1785-y.spa
dc.relation.referencesRosenberry, T.L. (1975-1). Acetylcholinesterase. Advances in Enzymology and Related Areas of Molecular Biology 43(1) 103-218. doi:10.1002/9780470122884.ch3spa
dc.relation.referencesRosenberry, T.L. (1975-2). Catalysis by acetylcholinesterase: Evidence that the rate-limiting step for acylation with certain substrates precedes general acid-base Catalysis. Proceedings of the National Academy of Sciences 72(10), 3834-3838. doi: 10.1073/pnas.72.10.3834.spa
dc.relation.referencesRueda, A, G., Carreño Otero, A, L., Duque, J. E., & Kouznetsov, V. V. (2018). Synthesis of new α-amino nitriles with insecticidal action on Aedes aegypti (Díptera: Culicidae). Revista Brasileira de Entomologia 62(2), 112-118. doi: org/10.1016/j.rbe.2018.01.004spa
dc.relation.referencesSaavedra, K., Strode, C., Flores, A., Garcia, S., Reyes, G., Ranson, H., Hemingway, J., & Black, W. (2014). Differential transcription profiles in Aedes aegypti detoxification genes after temephos selection. Insect Molecular Biology 23(2), 199-215. doi: 10.1111/imb.12073.spa
dc.relation.referencesSalvatore, R., Nagle, A., & Jung, K. (2002). Cesium effect:  High chemoselectivity in direct N-alkylation of amines. The Journal of Organic Chemistry 67(3), 674-683. doi: org/10.1021/ jo010643c.spa
dc.relation.referencesSchuenemeyer, J. H., & Drew, L. J. (2011). Statistics for Earth and Environmental Scientists. New Jersey: John Wiley & Sons. 11-57-59-109.spa
dc.relation.referencesSchuler, F. L., Ribeiro, E. M., Feitosa, I. M., Horovitz, D.D.G., Cavalcanti, D.P., Pessoa, A., Doriqui, M., Neri, J, I., Pina, N., Monteiro, W, H., Cernach, M., Antonette, S,H., Pone, M. V. S,.Serao, C., & Sanseverino, M.T.V. (2016). Possible association between Zika virus infection and microcephaly - Brazil, 2015. Morbidity and Mortality Weekly Report 65(3), 59-62. doi:org/10.15585/mmwr.mm6503e2external icon.spa
dc.relation.referencesShafran, Y., Bakulev, V., & Mokrushin, V. (1989). Synthesis and properties of α-aminonitriles. Russian Chemical Reviews 58(2), 148-162. doi: org/10.1070/RC1989v058n02A BEH003432.spa
dc.relation.referencesShan, C., Xie, X., Barrett, A., Garcia, M., Tesh, R., Vasconcelos., Vasilakis, N., Weaver, C. S. & Shi, P.Y. (2016). Zika virus: Diagnosis, therapeutics, and vaccine. ACS Infectious Diseases 2(3), 170-172. doi.org/10.1021/acsinfecdis.6b00030.spa
dc.relation.referencesSingh, C. B. Kavala, V., Samal, A., & Patel, B. K. (2007). Aqueous‐Mediated N‐Alkylation of amines. European Journal of Organic Chemistry, 2007(8), 1211-1383. doi: org/10.1002/ejoc.200600937.spa
dc.relation.referencesSinghal, S., Jain, S., & Sain, B. (2010). Heterogeneously catalyzed oxidative cyanation of tertiary amines with sodium cyanide/hydrogen peroxide using polymersupported iron(II) phthalocyanines as catalyst. Advanced Synthesis & Catalysis 352(8), 1338-1344. doi.org/ 10.1002/adsc.201000007.spa
dc.relation.referencesSteinman, M., Topliss, J. G., Alekel, R., Wong, Y. S. & York, E. (1974). 1-poly(fluoroalkyl)benzo diazepine. Journal of Medicinal Chemistry 16(12), 1354-13560. doi: org/10.1021/jm00270a008.spa
dc.relation.referencesSteinman, M., Topliss, J. G., Alekel, R., Wong, Y. S. & York, E. (1974). 1-poly(fluoroalkyl)benzo diazepine. Journal of Medicinal Chemistry 16(12), 1354-13560. doi: org/10.1021/jm00270a008.spa
dc.relation.referencesSymala, M. (2009). A decade of advances in three component reactions Organic Preparations and Procedures International 2(37), 103-171. doi: org/10.1080/00304940509354882spa
dc.relation.referencesTabashnik, B.E.; Mota-Sanchez, D.; Whalon, M.E.; Hollingworth, R.M.; Carrière, Y. (2014). Defining terms for proactive management of resistance to bt crops and pesticides. Journal of Economic Entomology 107(2), 496-507. doi: 10.1603/ec13458.spa
dc.relation.referencesTang, B. (2012). The cell biology of Chikungunya virus infection. Cellular Microbiology 14(9), 1354-1363. doi: org/10.1111/j.1462-5822.2012.01825.spa
dc.relation.referencesTaylor, P., Radic, Z. (1994). The cholinesterases: from genes to proteins. Annual Review of Pharmacology and Toxicology 34(1), 281-320. doi:10.1146/annurev.pa.34.040194.001433spa
dc.relation.referencesTorres, R. (2011). Determinación de la resistencia a insecticidas organofosforados, carbamatos y piretroides en tres poblaciones de Anopheles Albimanus (Diptera: Culicidae). Biomédica, 31(3), 419-427. doi: org/10.7705/biomedica.v31i3.388.spa
dc.relation.referencesUrbano, N. (2007). El endemismo: diferenciación del término, métodos y aplicaciones. Acta Zoológica Mexicana 33(1), 89-107.spa
dc.relation.referencesUS Environmental Protection Agency, (EPA). DEET. (2017). Consultado el 29 de agosto de 2018. De la fuente: https://www.epa.gov/insect-repellents/deet.spa
dc.relation.referencesVargas, L. Y., & Kouznetsov, V. V (2013). First girgensohnine analogs prepared through InCl3 catalized Current Organic Synthesis 10(6), 969-973 doi: 10.2174/157017941006140206105449spa
dc.relation.referencesVollhardt, K. Peter C.Schore, Neil E (2007) Organic chemistry Structure and function (EDS), 2da pp 1021-1022spa
dc.relation.referencesWang, J., Masui, Y., & Onaka. M. (2010). Synthesis of α-amino nitriles from carbonyl compounds, amines, and trimethylsilyl cyanide: comparison between catalyst-free conditions and the presence of tin ion-exchanged montmorillonite. European Journal of Organic Chemistry 1(9), doi: https://doi.org/10.1002/ejoc.200901323 1763-1771spa
dc.relation.referencesWoolhouse, M., Scott, F., Hudson, Z., Howey, R., & Chase, T.M. (2012). Human viruses: Discovery and emergence. Philosophical Transactions of the Royal Society B: Biological Sciences 367 (1604), 2864-2871. doi:10.1098/rstb.2011.0354spa
dc.relation.referencesWorld Health Organization (2018). Anual review of the blueprint list of priority diseases. Consultado el 21 de agosto de 2018. http://www.who.int/blueprint/priority-diseases/en/spa
dc.relation.referencesWorld Health Organization (WHO). (2019). Malaria. Consultado el 29 de agosto de 2018. De la fuente: http://www.who.int/mediacentre/factsheets/fs094/en/spa
dc.relation.referencesWorld Health Organization. (1957). Seventh Report Expert Committee on Insecticides. WHO Technical Report Series 125, 37. Consultado el 25 de junio de 2019. https://apps.who.int/ iris/handle/10665/40380.spa
dc.relation.referencesWorld Health Organization. (2005). Guidelines for laboratory and field testing of mosquito larvicida. Consultado el 24 de junio de 2016. http://apps.who.int/iris/bitstream/ 10665/69101/1/WHO_DS_WHOPES_GCDPP_2005.13.pdfspa
dc.relation.referencesWorld Health Organization. (2016). Zika situation report. Consultado el 5 de marzo de 2019. https://www.who.int/emergencies/zika-virus/situation-report/4-march-2016/en/spa
dc.relation.referencesZaim, Y., & Guillet, P. (2002). Alternative insecticides: An urgent need. Trends in Parasitology 18(4), 161-163. doi: 10.1371/journal.ppat.1001000spa
dc.relation.referencesZamora, V.I.S., Williams, E., & Johnson, C.N. (2012). Environmental temperature affects prevalence of blood parasites of birds on an elevation gradient: Implications for disease in a warming climate. 7(6), 208-239.spa
dc.relation.referencesZhang, Y., Peng, H., Zhang, M., Cheng, Y., & Zhu, C. (2011). Gold-complexes catalyzed oxidative α-cyanation of tertiary amines. Chemical Communications 47(8), 2354-2356. doi: 10.1039/C0CC01742F xxspa
dc.rights.accessrightsinfo:eu-repo/semantics/openAccess
dc.rights.coarhttp://purl.org/coar/access_right/c_abf2
dc.rights.localAbierto (Texto Completo)spa
dc.subject.keywordAedes aegypti,spa
dc.subject.keywordα-aminonitrilesspa
dc.subject.keywordlarvicidal activityspa
dc.subject.lembMosquitos-controlspa
dc.subject.lembEpidemiologíaspa
dc.subject.lembSalud públicaspa
dc.subject.lembInsectos-vectoresspa
dc.subject.proposalAedes aegyptispa
dc.subject.proposalα-aminonitrilosspa
dc.subject.proposalActividad larvicidaspa
dc.titleSíntesis, caracterización y estudio de la actividad larvicida de nuevos 2-[bencil(aril)amino]acetonitrilosspa
dc.typebachelor thesis
dc.type.categoryFormación de Recurso Humano para la Ctel: Trabajo de grado de Pregradospa
dc.type.coarhttp://purl.org/coar/resource_type/c_7a1f
dc.type.coarversionhttp://purl.org/coar/version/c_ab4af688f83e57aa
dc.type.driveinfo:eu-repo/semantics/bachelorThesis
dc.type.localTesis de pregradospa
dc.type.versioninfo:eu-repo/semantics/acceptedVersion

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