Estudio cienciométrico de la relación entre la estructura, actividad biológica y toxicidad de nanopartículas de plata y oro

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dc.contributor.advisorCervantes Díaz, Martha
dc.contributor.authorAguilar Acevedo, María Cecilia
dc.contributor.corporatenameUniversidad Santo Tomás
dc.date.accessioned2026-03-03T12:47:23Z
dc.date.available2026-03-03T12:47:23Z
dc.date.issued2026-03-02
dc.descriptionEl propósito de este trabajo fue analizar y caracterizar, desde un enfoque cienciométrico, la evolución y el estado del conocimiento sobre nanopartículas metálicas de plata (AgNPs) y oro (AuNPs), con énfasis en su actividad biológica, toxicidad, métodos de síntesis y proyección hacia la innovación científica y tecnológica. El estudio se orientó a identificar tendencias, vacíos de investigación y relaciones conceptuales que sirvan como base para investigaciones posteriores de carácter experimental y aplicado. La metodología se desarrolló mediante un enfoque documental y analítico en tres fases: (i) búsqueda y depuración del corpus científico y tecnológico, (ii) análisis cienciométrico de tendencias temporales, áreas de conocimiento y coocurrencia de términos, y (iii) minería de texto a partir de matrices relacionales. Para ello, se realizó una consulta sistemática de literatura científica en la base de datos Scopus y de documentos de patentes en Lens Patent, abarcando el periodo 2014–2025. El procesamiento y visualización de la información se apoyó en herramientas especializadas como VantagePoint, VOSviewer, Tree of Science y Bibliometrix. Los resultados evidencian una marcada centralización de la literatura en torno a las AgNPs, estrechamente vinculadas con propiedades fisicoquímicas como tamaño, morfología y química superficial, confirmando que la relación estructura–propiedad–respuesta biológica constituye el eje conceptual dominante del campo. Asimismo, se identificó que la actividad antibacteriana es la aplicación biológica más recurrente, con una tendencia creciente hacia el desarrollo de nanocompuestos y sistemas híbridos orientados a mejorar la estabilidad, la biocompatibilidad y el desempeño funcional. Finalmente, el análisis de patentes mostró una alta coherencia entre la producción científica y su proyección tecnológica, concentrada principalmente en aplicaciones biomédicas y procesos de síntesis de nanomateriales
dc.description.abstractThe aim of this study was to analyze and characterize, from a scientometric perspective, the evolution and current state of knowledge on silver (AgNPs) and gold (AuNPs) metallic nanoparticles, with emphasis on their biological activity, toxicity, synthesis methods, and projection toward scientific and technological innovation. The study sought to identify research trends, knowledge gaps, and conceptual relationships that may serve as a foundation for future experimental and applied research. The methodology was based on a documentary and analytical approach developed in three phases: (i) retrieval and refinement of the scientific and technological corpus, (ii) scientometric analysis of temporal trends, research areas, and term co-occurrence, and (iii) text mining through the construction of relational matrices. A systematic search of scientific literature was conducted using the Scopus database, along with patent documents retrieved from the Lens Patent database, covering the period from 2014 to 2025. Data processing and visualization were supported by specialized tools such as VantagePoint, VOSviewer, Tree of Science, and Bibliometrix. The results reveal a strong centralization of the scientific literature around AgNPs, closely associated with key physicochemical properties such as size, morphology, and surface chemistry, confirming that the structure–property–biological response relationship constitutes the dominant conceptual axis of the field. In addition, antibacterial activity was identified as the most recurrent biological application, with an increasing trend toward the development of nanocomposites and hybrid systems aimed at improving stability, biocompatibility, and functional performance. Finally, the patent analysis demonstrated a high level of coherence between scientific production and its technological projection, mainly concentrated on biomedical applications and nanomaterial synthesis processes.
dc.description.degreelevelMaestríaspa
dc.description.domainhttps://www.ustabuca.edu.co/
dc.format.mimetypeapplication/pdf
dc.identifier.citationAguilar Acevedo, M.C. (2026). Estudio cienciométrico de la relación entre la estructura, actividad biológica y toxicidad de nanopartículas de plata y oro [Tesis de posgrado]. Universidad Santo Tomás, Bucaramanga, Colombia.
dc.identifier.instnameinstname:Universidad Santo Tomásspa
dc.identifier.reponamereponame:Repositorio Institucional Universidad Santo Tomásspa
dc.identifier.repourlrepourl:https://repository.usta.edu.cospa
dc.identifier.urihttp://hdl.handle.net/11634/71823
dc.language.isospa
dc.publisherUniversidad Santo Tomásspa
dc.publisher.branchCRAI-USTA Bucaramanga
dc.publisher.facultyFacultad de Química Ambientalspa
dc.publisher.programMaestría Ciencias y Tecnologías Ambientalesspa
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dc.rights.accessrightsinfo:eu-repo/semantics/openAccess
dc.rights.coarhttp://purl.org/coar/access_right/c_abf2
dc.rights.localAbierto (Texto Completo)spa
dc.rights.localAbierto (Texto Completo)spa
dc.rights.localMagister en Ciencias y Tecnologías Ambientalesspa
dc.subject.keywordGold nanoparticles
dc.subject.keywordSilver nanoparticles
dc.subject.keywordBiological activity
dc.subject.keywordCytotoxicity
dc.subject.keywordAntimicrobial activity
dc.subject.proposalNanopartículas de oro
dc.subject.proposalNanopartículas de plata
dc.subject.proposalActividad biológica
dc.subject.proposalCitotoxicidad
dc.subject.proposalActividad antimicrobiana
dc.titleEstudio cienciométrico de la relación entre la estructura, actividad biológica y toxicidad de nanopartículas de plata y oro
dc.typemaster thesis
dc.type.categoryFormación de Recurso Humano para la Ctel: Trabajo de grado de Maestría
dc.type.coarhttp://purl.org/coar/resource_type/c_bdcc
dc.type.coarversionhttp://purl.org/coar/version/c_ab4af688f83e57aa
dc.type.driveinfo:eu-repo/semantics/masterThesis
dc.type.localTesis de maestríaspa
dc.type.versioninfo:eu-repo/semantics/acceptedVersion

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