The quantitative structure–insecticidal activity relationships from plant derived compounds against chikungunya and zika aedes aegypti (Diptera:Culicidae) vector

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dc.contributor.authorSaavedra, Laura M.spa
dc.contributor.authorRomanelli, Gustavo P.spa
dc.contributor.authorRozo, Ciro E.spa
dc.contributor.authorDuchowicz, Pablo R.spa
dc.coverage.campusCRAI-USTA Bogotáspa
dc.date.accessioned2019-06-06T21:10:23Zspa
dc.date.available2019-06-06T21:10:23Zspa
dc.date.issued2018-01-01spa
dc.description.abstractThe insecticidal activity of a series of 62 plant derivedmolecules against the chikungunya, dengue and zika vector, the Aedes aegypti (Diptera:Culicidae) mosquito, is subjected to a Quantitative Structure–Activity Relationships (QSAR) analysis. The Replacement Method (RM) variable subset selection technique based on Multivariable Linear Regression (MLR) proves to be successful for exploring 4885 molecular descriptors calculatedwith Dragon 6. The predictive capability of the obtained models is confirmed through an external test set of compounds, Leave- One-Out (LOO) cross-validation and Y-Randomization. The present study constitutes a first necessary computational step for designing less toxic insecticides.spa
dc.description.domainhttp://unidadinvestigacion.usta.edu.cospa
dc.format.mimetypeapplication/pdfspa
dc.identifier.citationSaavedra, L. M., Romanelli, G. P., Rozo, C. E., & Duchowicz, P. R. (2018). The quantitative structure–insecticidal activity relationships from plant derived compounds against chikungunya and zika aedes aegypti (diptera:Culicidae) vector. Bogotá: doi:10.1016/j.scitotenv.2017.08.119spa
dc.identifier.doihttps://doi.org/10.1016/j.scitotenv.2017.08.119spa
dc.identifier.urihttp://hdl.handle.net/11634/17049
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dc.rightsAtribución-NoComercial-CompartirIgual 2.5 Colombia*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/2.5/co/*
dc.subject.keywordInsecticidal activityspa
dc.subject.keywordChikungunyaspa
dc.subject.keywordZikaspa
dc.subject.keywordAedes aegyptispa
dc.subject.keywordQSAR theoryspa
dc.subject.keywordMLR analysisspa
dc.titleThe quantitative structure–insecticidal activity relationships from plant derived compounds against chikungunya and zika aedes aegypti (Diptera:Culicidae) vectorspa
dc.type.categoryGeneración de Nuevo Conocimiento: Artículos publicados en revistas especializadas - Electrónicosspa

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