Síntesis De Análogos De Curcumina Para La Detección Del pH

Abstract

It is essential to develop accurate and sustainable methods for pH measurement in various applications. Traditional methods such as potentiometers and pH strips have limitations due to the use of toxic materials and the generation of polluting waste. In this context, the synthesis of optical sensors based on curcumin analogues is a promising alternative due to their favorable properties such as high sensitivity, selectivity, biocompatibility study and low cost. The objective of this project is to synthesize and characterize new curcumin analogues for use as pH indicators by UV-Vis spectroscopy. The curcumin analogues in their obtaining and optimization of reactions; will be carried out, through various chemical synthesis procedures and using reported literature and their colorimetric and fluorescence responses will be evaluated in a pH range from 0 to 14. In addition, the toxicity of these compounds will be tested by ecotoxicity tests to determine their possible impact on the environment. The methodology includes sensor synthesis, calibration tests and fluorescence analysis, as well as structural characterization using instrumental techniques such as infrared spectroscopy and UV-Vis spectroscopy. The results are expected to enable the development of versatile and efficient optical sensors for pH measurement, with potential applications in the environmental monitoring, healthcare and agricultural industries. In addition, this project will advance research in organic synthesis and molecular sensing, providing a sustainable and efficient alternative to traditional pH determination methods.