Síntesis y caracterización del complejo órgano-mineral (Metoprolol Succinato- montmorillonita) para la liberación controlada del Metoprolol Succinato.

Abstract

Due to the current need to prolong the action of a drug and reduce the side effects that can be generated in the patient, because the active principle remains in the bloodstream, sometimes in a maximum concentration value that represents a toxic level for the organism, many scientific investigations have been developed that focus on the implementation of systems that cover the needs outlined above, thus giving rise to controlled release systems. These systems have the benefit of minimizing the amount of drug that is needed, since the release of the active principle is controlled and its concentration in the blood is optimal, thus achieving greater absorption. In this research work, the synthesis of the organo-mineral complexes Metoprolol Succinate (MPS) -montmorillonite (MMT) was carried out at different pH values (6 and 8), because pH is a determining factor in the intercalation of Metoprolol Succinate in montmorillonite. The presence of Metoprolol Succinate in the interlaminar space of the montmorillonite was determined by XRD of polycrystalline samples, and different complementary analytical techniques (UV-Vis, FTIR and SEM), obtaining as a result that MPS was introduced into the montmorillonite, where the largest incorporation of the drug occurred at pH 6, and these interactions are due to hydrogen bonds formed and ion-dipole interactions that occur between the amine group of the MPS and the interlayer layers of the negatively charged montmorillonite. Finally, the drug release kinetic profile was performed in the MPS-MMT complex synthesized at pH 8, through an in vitro study with buffer solutions of pH 1.4 and 7.2, for the simulation of gastric and intestinal fluids, respectively.