Study on the inhibitory effect of furafylline and troleandomycin in the 7 - methoxyresorufin - O - demethylase and nifedipine oxidase activities in hepatic microsomes from four poultry species using high-performance liquid chromatography coupled with fluorescence and ultraviolet detection

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dc.contributor.authorMurcia, Hansenspa
dc.contributor.authorCruz, Andrésspa
dc.contributor.authorLeón, Jeffreyspa
dc.contributor.authorGonzález-Curbelo, Miguel Ángelspa
dc.coverage.campusCRAI-USTA Bogotáspa
dc.date.accessioned2019-05-28T18:07:03Zspa
dc.date.available2019-05-28T18:07:03Zspa
dc.date.issued2018-10-17spa
dc.description.abstractThe present study reports the in vitro studies with furafylline and troleandomycin (TAO) as specific inhibitors of activities 7-methoxyresorufin-O-demethylase (MROD) and nifedipine oxidase, catalyzed by cytochrome P450 1A2 (CYP1A2) and 3A4 human enzymes, respectively, in hepatic microsomes of quail, duck,turkey and chicken. The results suggestthatin chicken and quailthe MROD activity is carried out by orthologs CYP1A4 and 1A5, meanwhile in duck and turkey by a CYP1A5 ortholog. The nifedipine oxidase activity is carried out by orthologs of the CYP3A family in the four bird species. The use of furafylline and TAO significantly decreased these activities (P < 0.05) and suggested that the biotransformation of resorufin methyl ether (RME) may be related to more than one avian ortholog.spa
dc.description.domainhttp://unidadinvestigacion.usta.edu.cospa
dc.format.mimetypeapplication/pdfspa
dc.identifier.citationGonzález-Curbelo, M. Á, León, J., Cruz, A., & Murcia, H. (2018). Study on the inhibitory effect of furafylline and troleandomycin in the 7 - methoxyresorufin - O - demethylase and nifedipine oxidase activities in hepatic microsomes from four poultry species using high-performance liquid chromatography coupled with fluorescence and ultraviolet detection. Bogotá: doi:10.1016/j.jpba.2018.10.031spa
dc.identifier.doihttps://doi.org/10.1016/j.jpba.2018.10.031spa
dc.identifier.urihttp://hdl.handle.net/11634/16902
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dc.rightsAtribución-NoComercial-SinDerivadas 2.5 Colombia*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/2.5/co/*
dc.subject.keywordFurafyllinespa
dc.subject.keywordTroleandomycinspa
dc.subject.keyword7-methoxyresorufin-O-demethylase activityspa
dc.subject.keywordNifedipine oxidase activityspa
dc.subject.keywordAvian orthologsaspa
dc.titleStudy on the inhibitory effect of furafylline and troleandomycin in the 7 - methoxyresorufin - O - demethylase and nifedipine oxidase activities in hepatic microsomes from four poultry species using high-performance liquid chromatography coupled with fluorescence and ultraviolet detectionspa
dc.type.categoryGeneración de Nuevo Conocimiento: Artículos publicados en revistas especializadas - Electrónicosspa

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