Revisión sistemática de la eficacia del uso del plasma rico en factores de crecimiento y su aplicación en periodoncia

Abstract

Introduction. Plasma Rich in Growth Factors (PRGF) is a cell derivative that is obtained as a product of blood centrifugation is favorable in tissue regeneration by obtaining autologous platelet and plasma proteins. There are several therapeutic applications that show that growth factors improve tissue regeneration and healing of soft and hard tissues in relation to their application in dentistry. Aim. Describe the efficacy of PRGF used as an adjunct in bone regeneration and healing of hard and soft tissues in dentistry. Methods. A systematic review of the databases Web of Science, Scopus, Dentistry & Oral Sciences Source and PubMed, which included clinical trials using the following keywords: ‘growth factor-rich plasma’, ‘periodontal medicine’, ‘prgf’. Articles older than 9 years of publication were excluded. Results. 223 articles were recovered after removing duplicates and studies that did not comply with inclusion criteria, 15 articles were finally chosen according to the selection parameters. The country with the most publications was Iran (44%), in 2017 the highest number of articles (31%) was evidenced and, most of the articles were reported in the English language (88%). Efficacy was measured using clinical parameters as pocket depth (PD) where six of the seven articles in which it was evaluated, did not show significant differences between the intervention group and the control group, the remaining article showed a significant difference at 6 and 12 months of treatment, but did not report the baseline PD means which made the analysis of the final result difficult. Another variable evaluated was the gingival index (GI) in four articles, which had significant results in the intragroup comparison, but there were no significant results in the intergroup comparison. Finally, 47% of the articles collected from the different databases showed a favorable result according to the objective set in each one of them. Conclusions. Articles that were previously rated by the Consort Guide 2010 were included. The studies showed favorable results for the use of PRGF in some clinical parameters; however, it is pertinent to continue with a periodic clinical and bibliographic follow-up on the efficacy of PRGF, since in the last decade it has been little reported in different treatments.