Síntesis, caracterización molecular y cristalográfica de compuestos metálicos de cu y ni con posible actividad biológica usando como ligandos bases de schiff

Abstract

The search of new biologically active compounds is a primordial area of human knowledge, due to the importance of finding new structures that can be employed as pharmaceutical products in the treatment of diseases. The organic synthesis provides a great number of compounds with specific biological activity. Particularly, the Schiff base and benzimidazole are attractive compounds in the search of antimicotic and antibacterial materials. Another aspect that must be considered is the use of biologically active compounds as ligands in the formation of coordination complexes, because it has been proven that the activity of these compounds can be enhanced be forming the coordination complexes in comparison to its organic free form. On that basis, in the present investigation project was determined a synthetic route to obtain these compounds, finding in the process of molecular and structural characterization that the proposed method, in certain cases, is not selective for the formation of the desired compounds. Additionally, alternative synthesis methods were studied following the principles of green chemistry finding a viable route to obtain the compounds of interest. Thereafter, these compounds were used for the synthesis of coordination complexes using Ni and Cu. Finally, powder and single crystal X-ray diffraction techniques were realized to identify and characterize structurally the obtained compounds. As main results it is to be noticed the environmental advantages that allows the synthetic process via alternative methods and the good structural characterization of the organic compounds and coordination complexes with possible antibacterial and antimicotic activity. Activity that will be evaluated in future investigation projects.