Effects of supervised exercise on cancer-related fatigue in breast cancer survivors: a systematic review and meta-analysis

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Effects of supervised exercise on cancer-related fatigue in breast cancer survivors: a systematic review and meta-analysis.pdf (1.4 MB)

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2015-02-21

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http://hdl.handle.net/11634/20427

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https://doi.org/10.1186/s12885-015-1069-4

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gruplac

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http://unidadinvestigacion.usta.edu.co

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Background: Cancer-related fatigue (CRF) is the most common and distressing symptom in breast cancer survivors. Approximately 40% to 80% of cancer patients undergoing active treatment suffer from CRF. Exercise improves overall quality of life and CRF; however, the specific effects of the training modalities are not well understood. Methods: This study aimed to determine the pooled effects of supervised exercise interventions on CRF in breast cancer survivors. We searched PubMed/MEDLINE, EMBASE, Scopus, CENTRAL and CINAHL databases between December 2013 and January 2014 without language restrictions. Risk of bias and methodological quality were evaluated using the PEDro score. Pooled effects were calculated with a random-effects model according to the DerSimonian and Laird method. Heterogeneity was evaluated with the I2 test. Results: Nine high-quality studies (n = 1156) were finally included. Supervised aerobic exercise was statistically more effective than conventional care in improving CRF among breast cancer survivors (SMD = −0.51, 95%CI −0.81 to −0.21), with high statistical heterogeneity (P = 0.001; I2 = 75%). Similar effects were found for resistance training on CRF (SMD = −0.41, 95%CI −0.76 to −0.05; P = 0.02; I2 = 64%). Meta-regression analysis revealed that exercise volume parameters are closely related with the effect estimates on CRF. Egger’s test suggested moderate evidence of publication bias (P = 0.04). Conclusions: Supervised exercise reduces CRF and must be implemented in breast cancer rehabilitation settings. High-volume exercises are safe and effective in improving CRF and overall quality of life in women with breast cancer. Further research is encouraged.

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Atribución-NoComercial-CompartirIgual 2.5 Colombia
Atribución-NoComercial-CompartirIgual 2.5 Colombia
http://creativecommons.org/licenses/by-nc-sa/2.5/co/
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