Challenges and perspectives of chemical biology, a successful multidisciplinary field of natural sciences
dc.contributor.author | Rojas-Ruiz, Fernando A. | |
dc.contributor.author | Vargas-Méndez, Leonor Y. | |
dc.contributor.author | Kouznetsov, Vladimir V. | |
dc.coverage.campus | CRAI-USTA Bogotá | spa |
dc.date.accessioned | 2020-01-22T17:57:44Z | |
dc.date.available | 2020-01-22T17:57:44Z | |
dc.date.issued | 2011-03-23 | |
dc.description.abstract | Objects, goals, and main methods as well as perspectives of chemical biology are discussed. This review is focused on the fundamental aspects of this emerging field of life sciences: chemical space, the small molecule library and chemical sensibilization (small molecule microassays). | spa |
dc.description.domain | http://unidadinvestigacion.usta.edu.co | spa |
dc.format.mimetype | application/pdf | spa |
dc.identifier.doi | https://doi.org/10.3390/molecules16032672 | spa |
dc.identifier.uri | http://hdl.handle.net/11634/21038 | |
dc.relation.references | Quinkert, G.; Wallmeier, H.; Windhab, N.; Reichert, D. Chemical Biology From Small Molecules to Systems Biology and Drug Design; Schreiber, S.L., Kupoor, T.M., Günther, W., Eds.; WileyVCH: Weinheim, Germany, 2007; Volume 1, Chapter 1, pp. 3-67. | spa |
dc.relation.references | Lodish, H.; Berk, A.; Kaiser, C.A.; Krieger, M.; Scott, M.P.; Bretscher, A.; Ploegh, H.; Matsudaira, P. Molecular Cell Biology; W.H. Freeman: Basingstoke, UK, 2008; pp. 1-3. | spa |
dc.relation.references | Waldmann, H.; Janning, P. Chemical Biology, A Practical Course; Wiley-VCH: Weinheim, Germany, 2004; pp. 1-3. | spa |
dc.relation.references | Sekhon, B.S. Chemical Biology: Past, Present and Future. Curr. Chem. Biol. 2008, 2, 278-311. | spa |
dc.relation.references | Gordon, E.J. Small-Molecule Screening: It Takes a Village. ACS Chem. Biol.2007, 2, 9-16. | spa |
dc.relation.references | Dobson, C. Chemical space and biology. Nature 2004, 432, 824-828. | spa |
dc.relation.references | Haggarty, S.J. The principle of complementary: Chemical versus biological space. Curr. Opin. Chem. Biol. 2005, 9, 296-303. | spa |
dc.relation.references | Wetzel, S.; Klein, K.; Renner, S.; Rauh, D.; Oprea, T.; Mutzel, P.; Waldmann, H. Interactive exploration of chemical space with Scaffold Hunter. Nat. Chem. Biol. 2009, 5, 581-583. | spa |
dc.relation.references | Renner, S.; Otterlo, W.; Dominguez, M.; Möcklinghoff, S.; Hofmann, B.; Wetzel, S.; Schuffenhauer, A.; Ertl, P.; Oprea, T.; Steinhilber, D. Bioactivity-guided mapping and navigation of chemical space. Nat. Chem. Biol. 2009, 5, 585-592. | spa |
dc.relation.references | Horton, D.A.; Bourne, G.T.; Mark, L.; Smythe, M.L. The Combinatorial Synthesis of Bicyclic Privileged Structures or Privileged Substructures. Chem. Rev. 2003, 103, 893-930. | spa |
dc.relation.references | Evans, B.E.; Rittle, K.E.; Bock, M.G.; DiPardo, R.M.; Freidinger, R.M.; Whitter, W.L.; Lundell, G.F.; Veber, D.F.; Anderson, P.S.; Chang, R.S.L.; Lotti, V.J.; Cerino, D.J.; Chen, T.B.; Kling, P.J.; Kunkel, K.A.; Springer, J.P.; Hirshfield, J. Methods for drug discovery: Development of potent, selective, orally effective cholecystokinin antagonists. J. Med. Chem. 1988, 31, 2235-2246. | spa |
dc.relation.references | Pitt, W.R.; Parry, D.M.; Perry, B.G.; Groom, C.R. Heteroaromatic Rings of the Future. J. Med. Chem. 2009, 52, 2952-2963. | spa |
dc.relation.references | Rush, T.S., III; Grant, J.A.; Mosyak, L.; Nicholls, A. A Shape-Based 3-D Scaffold Hopping Method and Its Application to a Bacterial Protein-Protein Interaction. J. Med. Chem. 2005, 48, 1489-1495. | spa |
dc.relation.references | Rosén, J.; Lovgren, A.; Kogej, T.; Muresan, S.; Gottfries, J.; Backlund, A. ChemGPS-NPWeb: Chemical space navigation online. J.Comput-Aided Mol. Des. 2009, 23, 253-259. | spa |
dc.relation.references | Kirkpatrick, P.; Ellis, C. Chemical space. Nature 2004, 432, 823. | spa |
dc.relation.references | Bohacek, R.S.; McMartin, C.;Guida, W.C. The art and practice of structure-based drug design: A molecular modeling perspective. Med. Res. Rev. 1996, 16, 3-50. | spa |
dc.relation.references | Van Deursen, R.; Reymond, J.L. ChemicalSpaceTravel. Chem. Med. Chem. 2007, 2, 636-640. | spa |
dc.relation.references | Fink, T.; Reymond, J.L. Virtual Exploration of the Chemical Universe up to 11 Atoms of C, N, O, F: Assembly of 26.4 Million Structures (110.9 Million Stereoisomers) and Analysis for New Ring Systems, Stereochemistry, Physicochemical Properties, Compound Classes, and Drug Discovery. J. Chem. Inf. Model 2007, 47, 342-353. | spa |
dc.relation.references | CAS. A Division of the American Chemical Society. http://www.cas.org/cgi-bin/cas/regreport.pl. (Accessed on 15 March 2011). | spa |
dc.relation.references | U.S. FDA, U.S. Department of Health and Human Services. http://www.fda.gov/Drugs/ DrugSafety/PostmarketDrugSafetyInformationforPatientsandProviders/UCM111085. (Accessed on 15 March 2011). | spa |
dc.rights | Atribución-NoComercial-CompartirIgual 2.5 Colombia | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-sa/2.5/co/ | * |
dc.subject.keyword | Chemical biology | spa |
dc.subject.keyword | Small molecule library | spa |
dc.subject.keyword | Chemical sensibilization | spa |
dc.title | Challenges and perspectives of chemical biology, a successful multidisciplinary field of natural sciences | spa |
dc.type.category | Generación de Nuevo Conocimiento: Artículos publicados en revistas especializadas - Electrónicos | spa |
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