Cacalol and cacalol acetate as photoproducers of singlet oxygen and as free radical scavengers, evaluated by EPR spectroscopy and TBARS

Vista sencilla de ítem
dc.contributor.authorGomez-Vidales, Virginia
dc.contributor.authorGranados-Oliveros, Gilma
dc.contributor.authorNieto-Camacho, Antonio
dc.contributor.authorReyes-Solís, Mirna
dc.contributor.authorJimenez-Estrada, Manuel
dc.date.accessioned2020-01-21T13:07:24Z
dc.date.available2020-01-21T13:07:24Z
dc.date.issued2013-11-06
dc.description.abstractPhotodynamic therapy (PDT) is an emerging cancer treatment based on the production of singlet oxygen (1O2) upon illumination of a photosensitizer in the presence of oxygen. Antioxidants are primarily reducing agents prone to scavenge reactive species in one way or another. Cacalol (C) and cacalol acetate (CA) were examined and compared regarding to their capacity to produce singlet oxygen and as scavengers of free radicals. Their role as singlet oxygen photoproducers under UV-vis light irradiation was examined by electron paramagnetic resonance (EPR) using 2,2,6,6-tetramethyl-piperidine (TEMP) as spin-trapping material. The quantum yield to produce 1O2 was found to be 0.4 ± 0.05 for CA and 0.13 ± 0.05 for C. Their properties as scavengers of hydroxyl (˙OH), nitrogen-centered (2,2-diphenyl-1-picryhydrazyl radical, DPPH˙) and organic radicals (R˙ and ROO˙) were evaluated using EPR and the thiobarbituric reactive substances (TBARS) method. C and CA differed in their abilities to trap DPPH˙. By contrast, both compounds showed similar activity to trap ˙OH, R˙ and ROO˙. A relationship between the redox potentials of the compounds and their activity as scavengers of DPPH˙ was observed. The producing/inhibiting properties showed by C and CA make them interesting options for new therapeutic applications to treat tumors and other diseases.spa
dc.description.domainhttp://unidadinvestigacion.usta.edu.cospa
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1039/c3ra42848fspa
dc.identifier.urihttp://hdl.handle.net/11634/20894
dc.publisher.branchCRAI-USTA Bogotáspa
dc.relation.referencesM. Ochsner, J. Photochem. Photobiol., B, 1997, 39, 1.spa
dc.relation.referencesA. Krieger-Liszkay, C. Fufezan and A. Trebst, Photosynth. Res., 2008, 98, 551.spa
dc.relation.references(a) T. J. Dougherty, C. J. Gomer, B. W. Henderson, G. Jori, D. Kessel, M. Korbelik, J. Moan and Q. Peng, J. Natl. Cancer Inst., 1998, 90, 889; (b) K. R. Weishaupt, C. J. Gomer and T. J. Dougherty, Cancer Res., 1976, 36, 2326.spa
dc.relation.referencesA. L. Anaya, B. E. Hernandez Bautista, A. Torres Barragan, J. Leon Cantero and M. Jimenez Estrada, J. Chem. Ecol., 1996, 22, 393.spa
dc.relation.referencesA. M. Braun and M. M.-T. E. Oliveros, Photochemical Technology, Wiley, Chichester (U. K.), 1991.spa
dc.relation.referencesM. Jimenez-Estrada, R. R. Chilpa, T. R. Apan, F. Lledias, W. Hansberg, D. Arrieta and F. J. A. Aguilar, J. Ethnopharmacol., 2006, 105, 34.spa
dc.relation.referencesB. Lotinahennsen, J. L. Roqueresendiz, M. Jimenez and M. Aguilar, Z. Naturforsch. C. J. Bioscis., 1991, 46, 777.spa
dc.relation.referencesK. Shindo, M. Kimura and M. Iga, Biosci., Biotechnol., Biochem., 2004, 68, 1393.spa
dc.relation.referencesM. Jimenez-Estrada, R. Reyes-Chilpa, A. Navarro-Ocana and D. Arrieta-Baez, Nat. Prod. Commun., 2008, 3, 479.spa
dc.relation.referencesW. Liu, E. Furuta, K. Shindo, M. Watabe, F. Xing, P. R. Pandey, H. Okuda, S. K. Pai, L. L. Murphy, D. L. Cao, Y. Y. Mo, A. Kobayashi, M. Iiizumi, K. Fukuda, B. Xia and K. Watabe, Breast Cancer Res. Treat., 2011, 128, 57.spa
dc.relation.referencesJ. N. Demas, W. D. Bowman, E. F. Zalewski and R. A. Velapoldi, Determination of the quantum yield of the ferrioxalate actinometer with electrically calibrated radiometers, J. Phys. Chem., 1981, 85, 2766.spa
dc.relation.referencesJ. Jakus and O. Farkas, Photochem. Photobiol. Sci., 2005, 4, 694.spa
dc.relation.referencesG. J. Bachowski, K. M. Morehouse and A. W. Girotti, Photochem. Photobiol., 1988, 47, 635.spa
dc.relation.referencesV. O. Melnikova, L. N. Bezdetnaya, D. Brault, A. Y. Potapenko and F. Guillemin, Int. J. Cancer, 2000, 88, 798.spa
dc.relation.referencesS. B. Powles, Annu. Rev. Plant Physiol. Plant Mol. Biol., 1984, 35, 15.spa
dc.relation.referencesC. Walling, Acc. Chem. Res., 1975, 8, 125spa
dc.relation.references(a) G. Jori, M. Beltramini, E. Reddi, B. Salvato, A. Pagnan, L. Ziron, L. Tomio and T. Tsanov, Cancer Lett., 1984, 24, 291; (b) J. W. Heinecke, Free Radical Biol. Med., 1987, 3, 65.spa
dc.relation.references(a) D. Jamieson, Free Radical Biol. Med., 1989, 7, 87; (b) R.-Y. Denq and I. Fridovich, Free Radical Biol. Med., 1989, 6, 123–129.spa
dc.relation.referencesF. Wilkinson, W. P. Helman and A. B. Ross, J. Phys. Chem. Ref. Data, 1993, 22, 113.spa
dc.relation.referencesS. Rinalducci, J. Z. Pedersen and L. Zolla, Biochim. Biophys. Acta, 2004, 1608, 63.spa
dc.rightsAtribución-NoComercial-CompartirIgual 2.5 Colombia
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/2.5/co/
dc.subject.keywordPhotodynamic therapy (PDT)spa
dc.subject.keywordCacalolspa
dc.subject.keywordCacalol acetatespa
dc.subject.keywordSinglet oxygenspa
dc.subject.keywordCancer treatmentspa
dc.titleCacalol and cacalol acetate as photoproducers of singlet oxygen and as free radical scavengers, evaluated by EPR spectroscopy and TBARSspa
dc.type.categoryGeneración de Nuevo Conocimiento: Artículos publicados en revistas especializadas - Electrónicosspa

Archivos

Bloque original

Mostrando 1 - 1 de 1
Miniatura
Nombre:
Cacalol and cacalol acetate as photoproducers of singlet oxygen and as free radical scavengers, evaluated by EPR spectroscopy and TBARS.pdf
Tamaño:
436.52 KB
Formato:
Adobe Portable Document Format
Descripción:
Artículo SCOPUS
Descargar

Bloque de licencias

Mostrando 1 - 1 de 1
Miniatura
Nombre:
license.txt
Tamaño:
807 B
Formato:
Item-specific license agreed upon to submission
Descripción:
Descargar

Colecciones

Producción de Alto Impacto