dc.contributor.author	Libardo Rojas, Jose	spa
dc.contributor.author	Garzón, Diego	spa
dc.contributor.author	Narváez, Carlos	spa
dc.contributor.author	López, Oscar	spa
dc.contributor.cvlac	http://scienti.colciencias.gov.co:8081/cvlac/visualizador/generarCurriculoCv.do?cod_rh=0000531359	spa
dc.contributor.cvlac	http://scienti.colciencias.gov.co:8081/cvlac/visualizador/generarCurriculoCv.do?cod_rh=0000130989	spa
dc.contributor.cvlac	http://scienti.colciencias.gov.co:8081/cvlac/visualizador/generarCurriculoCv.do?cod_rh=0000195065	spa
dc.contributor.cvlac	https://scienti.colciencias.gov.co/cvlac/visualizador/generarCurriculoCv.do?cod_rh=0000621803	spa
dc.contributor.googlescholar	https://scholar.google.es/citations?user=V0oEE7cAAAAJ&hl=es	spa
dc.contributor.googlescholar	https://scholar.google.com/citations?user=Q4OJ8mQAAAAJ&hl=es	spa
dc.contributor.googlescholar	https://scholar.google.es/citations?user=E1Fw2WcAAAAJ&hl=es&oi=ao	spa
dc.contributor.googlescholar	https://scholar.google.es/citations?user=hhrFXnIAAAAJ&hl=es&oi=ao	spa
dc.contributor.orcid	https://orcid.org/0000-0001-7845-1299	spa
dc.contributor.orcid	https://orcid.org/0000-0002-0359-839X	spa
dc.contributor.orcid	https://orcid.org/0000-0001-5750-2923	spa
dc.contributor.orcid	https://orcid.org/0000-0001-6102-9841	spa
dc.coverage.campus	CRAI-USTA Bogotá	spa
dc.date.accessioned	2020-04-20T16:21:04Z	spa
dc.date.available	2020-04-20T16:21:04Z	spa
dc.date.issued	2019-08	spa
dc.description	El hueso trabecular es una compleja estructura tridimensional, consiste en placas y laminillas que delimitan cavidades en las que se ubica la médula ósea, se produce a partir de un molde de cartílago de crecimiento mediante la osificación endocondral y alcanza su madurez morfológica durante el crecimiento por el modelado y remodelado óseo. El estímulo mecánico es altamente influyente en el proceso celular del desarrollo de este tejido, un desbalance del estímulo produce la variación en la expresión y diferenciación celular que conllevan a patologías que impiden su correcto desarrollo. Los modelos computacionales mecano-biológicos emplean varias herramientas de la mecánica de medio continuo. Específicamente emplean leyes de conservación que en conjunto con ecuaciones constitutivas correctamente planteadas pueden simular el comportamiento de los tejidos biológicos. En esta propuesta de investigación se presenta la planeación que orientará la ejecución de un modelo mecanobiológico de daño que permita estudiar el efecto del estímulo mecánico en la producción de microfracturas en las trabéculas por la variación en la expresión y diferenciación celular.	spa
dc.description.abstract	Trabecular bone is a complex three-dimensional structure, consisting of plates and lamella that delimit cavities in which the bone marrow is located, is produced from a growth cartilage mold by endochondral ossification, and reaches morphological maturity during growth by bone modeling and remodeling. The mechanical stimulus is highly influential in the cellular process of the development of this tissue, an imbalance of the stimulus produces the variation in cellular expression and differentiation that lead to pathologies that impede its correct development. Mechanical-biological computational models employ various tools of continuous medium mechanics. Specifically, they use conservation laws that together with correctly formulated constitutive equations can simulate the behavior of biological tissues. This research proposal presents the planning that will guide the execution of a mechanobiological model of damage that allows studying the effect of the mechanical stimulus on the production of microfractures in the trabeculae by variation in cell expression and differentiation.	spa
dc.description.domain	http://unidadinvestigacion.usta.edu.co	spa
dc.format.mimetype	application/pdf	spa
dc.identifier.uri	http://hdl.handle.net/11634/22616
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dc.relation.references	K. I. Tsubota, Y. Suzuki, T. Yamada, M. Hojo, A. Makinouchi, and T. Adachi, “Computer simulation of trabecular remodeling in human proximal femur using large-scale voxel FE models: Approach to understanding Wolff’s law,” J. Biomech., vol. 42, no. 8, pp. 1088–1094, 2009	spa
dc.relation.references	B. Depalle, R. Chapurlat, H. Walter-Le-Berre, B. Bou-Saïd, and H. Follet, “Finite element dependence of stress evaluation for human trabecular bone,” J. Mech. Behav. Biomed. Mater., vol. 18, pp. 200–212, 2013	spa
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dc.relation.references	M. M. A. Peyroteo, J. Belinha, S. Vinga, L. M. J. S. Dinis, and R. M. Natal Jorge, “Mechanical bone remodelling: Comparative study of distinct numerical approaches,” Eng. Anal. Bound. Elem., vol. 100, no. January 2018, pp. 125–139, 2019	spa
dc.rights	Atribución-NoComercial-SinDerivadas 2.5 Colombia	*
dc.rights.uri	http://creativecommons.org/licenses/by-nc-nd/2.5/co/	*
dc.subject.keyword	Biomechanics	spa
dc.subject.keyword	Mechanobiology	spa
dc.subject.keyword	Finite elements	spa
dc.subject.keyword	Primary trabecular bone	spa
dc.subject.proposal	Biomecánica	spa
dc.subject.proposal	Mecanobiología	spa
dc.subject.proposal	Elementos finitos	spa
dc.subject.proposal	Hueso trabecular primario	spa
dc.title	Modelo mecanobiológico de daño a escala micro en hueso trabecular primario	spa
dc.type.category	Formación de Recurso Humano para la Ctel: Proyecto ejecutado con investigadores en empresas, industrias y Estado	spa

Modelo mecanobiológico de daño a escala micro en hueso trabecular primario

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