The effect of orthodontic forces on calcitonin gene-related peptide expression in human dental pulp
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2011-07
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Abstract
Introduction: The purpose of this study was to quantify
the effect of moderate and severe orthodontic forces on
calcitonin gene-related peptide (CGRP) expression in
healthy human dental pulp. Methods: Thirty human
dental pulp samples were obtained from healthy premolars in which extraction was indicated for orthodontic
reasons. Before extraction, teeth were divided into 3
groups of 10 premolars each: (1) the control group:
healthy premolars without application of orthodontic
forces; (2) the moderate force group: a 56-g force was
applied to the premolars for 24 hours; and (3) the severe
force group: a 224-g force was applied to the premolars
for 24 hours. All dental pulp samples were processed,
and CGRP was measured by radioimmunoassay.
Results: Greater CGRP expression was found in the
severe force group followed by the moderate force
group. The lower CGRP values were for the control
group. The Kruskal-Wallis test showed statistically
significant differences between groups (P < .0001).
Least significant difference (LSD) post hoc tests showed
statistically significant differences in CGRP expression
between the control group and the severe force group
(P < .0001) but not with the moderate force group
(P = .06). Differences between the moderate and severe
force groups were statistically significant (P < .0001).
Conclusions: CGRP expression in human dental pulp
increases when teeth are submitted to severe orthodontic forces.
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Atribución-NoComercial-CompartirIgual 2.5 Colombia