Asociación de lesiones premalignas y malignas en cavidad oral con el virus del papiloma humano. Revisión sistemática

Abstract

In oral cavity, increasingly common is the presence of premalignant and malignantlesions, which occur frequently located in upper and lower lips , cheek mucosa , gingiva , palate and tongue. It is important to systematically review the association between HPV and premalignant and malignant lesions in the oral cavity. A systematic review of scientific articles showing the association between premalignant and malignant lesions in the oral cavity with HPV, considering diagnostic methods for the detection of virus was performed. The universe was made up articles that were found at the base of Scopus and Embase data. The sample included scientific articles cohort studies, case-control and cross-sectional expressing the aforementioned association. The information is systematized in Microsoft Excel. It was possible to demonstrate a positive association between human papillomavirus and oral cancer, specifically for squamous cell carcinoma. The diagnostic method of choice in 100% of the articles was the polymerase chain reaction (PCR) .In the articles analyzed low quality compliance was evident to account criteria such as the treatment of missing data, plus the inclusion of a flowchart and analysis of potential bias was limited. The most effective method in the diagnosis of HPV in premalignant and malignant lesions in the oral cavity is the PCR. Serotypes most frequently associated with premalignant and malignant lesions in the oral cavity were HPV16 and HPV18 serotype mainly related to squamous cell carcinoma.