Diseño de Sensores Moleculares Basados en Análogos de Curcuminas para la Detección del Herbicida Glifosato

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dc.contributor.advisorOsorio Martínez, Carlos Alberto
dc.contributor.authorCarrillo Martínez, Stephanya
dc.date.accessioned2024-07-05T20:35:02Z
dc.date.available2024-07-05T20:35:02Z
dc.date.issued2024
dc.descriptionEn la actualidad, la contaminación por parte de productos químicos orgánicos sigue siendo un reto a nivel mundial para el desarrollo sostenible ya que países en vías de desarrollo y desarrollados utilizan millones de compuestos orgánicos sintéticos para fines industriales, comerciales y de defensa. En sus aplicaciones comunes se encuentran presenten los plaguicidas, este gran grupo se subdivide dependiendo su uso; los herbicidas se aplican directamente a las plantas y suelos y como resultado se liberan compuestos orgánicos que ingresan al medio ambiente y causan contaminación en agua, suelo y aire. Algunos de estos contaminantes representan peligros en la salud como asma, alteraciones de nacimiento e incluso la muerte por lo tanto es fundamental hacer un monitoreo ambiental para evitar que posibles toxinas sean liberadas al medio. Las agencias de protección ambiental y los ministerios de ambiente del mundo estipulan regulaciones estrictas sobre las concentraciones de varios contaminantes ambientales incluidos los herbicidas para agua, suelo y aire, sin embargo, los métodos de monitoreo para la mayor parte de estos compuestos son costosos, requieren mucho tiempo y algunos presentan limitaciones en las técnicas de muestreo y posteriormente su análisis, por lo que debido a esto se presenta una gran demanda en desarrollar métodos más rápidos, simples y confiables para la detección de herbicidas agrícolas. La curcumina presenta una amplia gama de acciones fisiológicas como, efectos antitumorales, antiinflamatorios, antitrombóticos, antidiabéticos y antimicrobianos; este compuesto tanto en su forma natural como la modificada sintéticamente se puede utilizar como material de partida para la detección de productos químicos debido a sus propiedades ópticas como un polifenol fluorescente. El presente trabajo de investigación comprende la preparación de sensores químicos análogos de curcumina modificados y la obtención de una serie de complejos metálicos de cobre (Cu+2). Estas variaciones estructurales incluyen modificación de los grupos donadores de electrones en los materiales de partida, el uso de disolventes adecuados para lograr mejoras en los procesos de absorción-emisión si presentan propiedades fluorescentes y/o cambios colorimétricos en la evaluación para la detección analítica del herbicida glifosato.spa
dc.description.abstractCurrently, pollution by organic chemicals continues to be a global challenge for sustainable development since developing and developed countries use millions of synthetic organic compounds for industrial, commercial and defense purposes. In their common applications, pesticides are present, this large group is subdivided depending on their use; herbicides are applied directly to plants and soils and as a result, organic compounds are released that enter the environment and cause pollution in water, soil and air. Some of these pollutants represent health hazards such as asthma, birth disorders and even death, therefore it is essential to do environmental monitoring to prevent possible toxins from being released into the environment. Environmental protection agencies and environmental ministries around the world stipulate strict regulations on the concentrations of various environmental pollutants including herbicides for water, soil and air, however, monitoring methods for most of these compounds are expensive, time-consuming and some have limitations in sampling techniques and subsequently their analysis, so due to this there is a great demand to develop faster, simpler and more reliable methods for the detection of agricultural herbicides. Curcumin has a wide range of physiological actions such as antitumor, anti-inflammatory, antithrombotic, antidiabetic and antimicrobial effects; this compound both in its natural and synthetically modified form can be used as a starting material for the detection of chemical products due to its optical properties as a fluorescent polyphenol. The present research work includes the preparation of modified curcumin analogous chemical sensors and the obtaining of a series of copper metal complexes (Cu+2). These structural variations include modification of electron donor groups in source materials, the use of appropriate solvents to achieve improvements in absorption-emission processes if they have fluorescent properties and/or colorimetric changes in the evaluation for the analytical detection of the herbicide glyphosate.spa
dc.description.degreelevelPregradospa
dc.description.degreenameQuímico Ambientalspa
dc.description.domainhttps://www.ustabuca.edu.co/spa
dc.format.mimetypeapplication/pdf
dc.identifier.citationCarrillo Martínez, S. (2024). Diseño de Sensores Moleculares Basados en Análogos de Curcuminas para la Detección del Herbicida Glifosato. [Trabajo de pregrado], Universidad Santo Tomás, Bucaramanga, Colombiaspa
dc.identifier.instnameinstname:Universidad Santo Tomásspa
dc.identifier.reponamereponame:Repositorio Institucional Universidad Santo Tomásspa
dc.identifier.repourlrepourl:https://repository.usta.edu.cospa
dc.identifier.urihttp://hdl.handle.net/11634/56016
dc.language.isospa
dc.publisherUniversidad Santo Tomásspa
dc.publisher.branchCRAI-USTA Bucaramangaspa
dc.publisher.facultyFacultad de Química Ambientalspa
dc.publisher.programPregrado Química Ambientalspa
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dc.rightsAtribución-NoComercial-SinDerivadas 2.5 Colombia
dc.rightsAtribución-NoComercial-SinDerivadas 2.5 Colombia
dc.rights.accessrightsinfo:eu-repo/semantics/openAccess
dc.rights.coarhttp://purl.org/coar/access_right/c_abf2spa
dc.rights.localAbierto (Texto Completo)spa
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/2.5/co/
dc.subject.keywordAmino acidsspa
dc.subject.keywordMetal complexesspa
dc.subject.keywordCurcuminsspa
dc.subject.keywordFluorescencespa
dc.subject.keywordGlyphosatespa
dc.subject.keywordHerbicidesspa
dc.subject.keywordChemical sensorsspa
dc.subject.lembProductos químicosspa
dc.subject.lembAnálsis de compuestos químicosspa
dc.subject.lembProductos químicos orgánicosspa
dc.subject.proposalAminoácidospa
dc.subject.proposalComplejos metálicosspa
dc.subject.proposalCurcuminasspa
dc.subject.proposalFluorescenciaspa
dc.subject.proposalGlifosatospa
dc.subject.proposalHerbicidasspa
dc.subject.proposalSensores químicosspa
dc.titleDiseño de Sensores Moleculares Basados en Análogos de Curcuminas para la Detección del Herbicida Glifosatospa
dc.type.categoryFormación de Recurso Humano para la Ctel: Trabajo de grado de Pregradospa
dc.type.coarhttp://purl.org/coar/resource_type/c_7a1f
dc.type.coarversionhttp://purl.org/coar/version/c_ab4af688f83e57aa
dc.type.coarversionhttp://purl.org/coar/version/c_ab4af688f83e57aa
dc.type.driveinfo:eu-repo/semantics/bachelorThesis
dc.type.localTrabajo de gradospa
dc.type.versioninfo:eu-repo/semantics/acceptedVersion

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