Evaluación de las concentraciones de acetaminofén presentes en la Planta de Tratamiento de Aguas Residuales de la Universidad Pontificia Bolivariana-Seccional Bucaramanga y su efecto tòxico sobre el Allium Cepa

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dc.contributor.advisorCerón, Alexandraspa
dc.contributor.advisorCervantes Díaz, Marthaspa
dc.contributor.authorQuintero, Claudia Sofíaspa
dc.coverage.campusCRAI-USTA Bucaramangaspa
dc.date.accessioned2020-02-07T22:29:03Z
dc.date.available2020-02-07T22:29:03Z
dc.date.issued2020-02-05spa
dc.descriptionActualmente, el acetaminofén (ACE) es el analgésico más utilizado en la prevención, diagnóstico y tratamiento de enfermedades en humanos y animales, que finalmente se dispone en el agua al ser excretado en la orina y heces fecales y que finalmente llegan a las plantas de aguas residuales (PTARs) las cuales han sido diseñadas y construidas principalmente para remover materia orgánica y en menor grado nutrientes y microorganismos. Por lo tanto, estimar la concentración la concentración del acetaminofén en la PTAR UPB, constituye un gran avance en la región, ya que la Universidad Pontificia Bolivariana, es la única institución académica que posee un sistema de tratamiento para sus aguas residuales. Adicionalmente, el efluente es vertido en un cuerpo de agua superficial (Quebrada Menzuly), por lo que es de importancia analizar la concentración efectiva del acetaminofén, con el fín de analizar con aproximación su influencia ecotoxicológica. En este estudio se evaluó la concentración del acetaminofén en la planta de tratamiento de aguas residuales de la Universidad Pontificia Bolivariana (PTAR – UPB) en las muestras procendentes del Afluente, Reactor de Flujo a Pistón y Efluente, junto con los lodos utilizando cromatografía de alta resolución (HPLC), adicionalmente se evaluó efecto tóxico empleando como bioindicador el Allium Cepa. Los resultados obtenidos de las matrices extraídas (extracción líquido-líquido) de los lodos y muestras líquidas que fueron analizadas por HPLC, arrojaron datos con un coeficiente de variación entre 0.3% en matrices líquidas y 10% en lodos, porcentajes de recuperación entre 92% -101% en matrices líquidas y y límite de detección de 20 ng/L. Las desviaciones entre los valores obtenidos son pequeños y se deben a la influencia de la matriz y pretratamiento de la muestra. Los resultados muestran concentraciones de acetaminofén entre 460 ng/L y 80 ng/L en el afluente y efluente, respectivamente. En los lodos del reactor de flujo a pistón se obtuvo una concentración 5.2 mg/Kg y en los lechos de secado de 3.4 mg/Kg. La remoción obtenida en la PTAR- UPB por degradación varía entre 88% y 91%, por sorción fue 12% y un 34.7% permaneció en el efluente final. De acuerdo con lo anterior, en la PTAR predominó el proceso de degradación del acetaminofén en la fase líquida y la adsorción en los lodos fue menor. La evaluación ecotoxicológica del acetaminofén (método Allium Cepa) evidenció que la concentración encontrada en el efluente final es menor que la concentración efectiva hallada en el patrón puro (45.34 ppm) y en la pastilla (139.5 ppm), indicando que el contenido de acetaminofén en el efluente no es potencialmente tóxico.spa
dc.description.abstractAt the end of XX century, scientists have been worried about increase of acetaminophen (ACE)consumption, that increase its concentration and toxic effects, due to concentration in sewage and rivers, springs. Aditionally, its frequency of disposal in urine and stool make to acetaminophen increase its presence in sewage of waste wáter treatment plants whose desing is based on organic matter remotion and solids, otherwise microorganisms and other nutrients in low grade, This investigation takes into account two stages: First, to be know (ACE) concentration, its relevant results are related to new knowledge, because PTAR UPB just only treatment system build in academyc institution in Floridablanca-Santader. Aditionally, final effluent is pourted in a Menzuly spring, for that reason to know is very important to know ecotoxicological influence. The methodology based on High Performance Liquid Chromatography was used for the characterization of acetaminophen showed a precision with coefficient of variation between 0.3% -10%, recovery percentages between 92% -101%, detection limit of 20 ng /, the deviations between the low obtained values could be related to the influence of the matrix and pretreatment of the sample. The results showed acetaminophen concentrations between 460 ng / L and 80 ng / L in the tributary and effluent respectively. In the case of Reactor sludge, 5.2 mg / kg and Drying Beds of 3.4 mg / kg were obtained. The removal obtained in the plant by degradation varied between 88% and 91%, per 12% sore and 34.7% remain in the final effluent. Thus, drug removal processes are favored in the liquid phase and the solid phase adsorption phenomenon. The ecotoxicological evaluation of acetaminophen (Allium cepa method) threw values in the pure standard (45.34 ppm) and tablet (139.5 ppm), this indicates that the content of acetaminophen in the Effluent is not potentially toxic.spa
dc.description.degreelevelMaestríaspa
dc.description.degreenameMagister en Ciencias y Tecnologías Ambientalesspa
dc.description.domainhttps://www.ustabuca.edu.co/spa
dc.format.mimetypeapplication/pdfspa
dc.identifier.citationQuintero Duque. C. S (2020) Evaluación de las concentraciones de acetaminofén presentes en la Planta de Tratamiento de Aguas Residuales de la Universidad Pontificia Bolivariana-Seccional Bucaramanga y su efecto tóxico sobre el Allium Cepa [Tesis de maestría] Universidad Santo Tomás. Bucaramanga,Colombia.spa
dc.identifier.instnameinstname:Universidad Santo Tomásspa
dc.identifier.reponamereponame:Repositorio Institucional Universidad Santo Tomásspa
dc.identifier.repourlrepourl:https://repository.usta.edu.cospa
dc.identifier.urihttp://hdl.handle.net/11634/21502
dc.language.isospaspa
dc.publisherUniversidad Santo Tomásspa
dc.publisher.facultyFacultad de Química Ambientalspa
dc.publisher.programMaestría Ciencias y Tecnologías Ambientalesspa
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dc.relation.referencesTrejos, N., & Myriam, C. (2008). Validación de una metodología analítica por HPLC para la cuantificación de sulfadiazina de plata en crema Validation of an analytical methodology by HPLC for the quantification of silver sulfadiazine in cream. 37(2), 191–199.spa
dc.relation.referencesVancouver Island University, U. (2008). Acetaminophen ( Tylenol ) : A Pain to the Environment. Environmental Organic Chemistry, (12), 2008.spa
dc.relation.referencesVerma, A., Nimana, B., Olateju, B., Rahman, M. M., Radpour, S., Canter, C., … Kumar, A. (2017). A techno-economic assessment of bitumen and synthetic crude oil transport (SCO) in the Canadian oil sands industry: Oil via rail or pipeline? Energy. https://doi.org/10.1016/j.energy.2017.02.057spa
dc.relation.referencesWalters, E., McClellan, K., & Halden, R. U. (2010). Occurrence and loss over three years of 72 pharmaceuticals and personal care products from biosolids-soil mixtures in outdoor mesocosms. Water Research, 44(20), 6011–6020. https://doi.org/10.1016/j.watres.2010.07.051spa
dc.relation.referencesXiao, H., Song, H., Xie, H., Huang, W., Tan, J., & Wu, J. (2013). Transformation of acetaminophen using manganese dioxide - mediated oxidative processes: Reaction rates and pathways. Journal of Hazardous Materials, 250–251, 138–146. https://doi.org/10.1016/j.jhazmat.2013.01.070spa
dc.relation.referencesYamamoto, H., Nakamura, Y., Moriguchi, S., Nakamura, Y., Honda, Y., Tamura, I., … Sekizawa, J. (2009). Persistence and partitioning of eight selected pharmaceuticals in the aquatic environment: laboratory photolysis, biodegradation, and sorption experiments. Water Research, 43(2), 351–362. https://doi.org/10.1016/j.watres.2008.10.039spa
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dc.relation.referencesRojas Mantilla Astrid Dayana, T. D. (2016). Estudio de la presencia, ocurrencia y destino final, de un compuesto farmacéutico (acetaminofén) en una planta de tratamiento de agua residual instituacional educativa. Bucaramanga : Universidad Pontificia Bolivariana.No Title (Universidad Pontificia Bolivariana-Seccional Bucaramanga.). https://doi.org/NAspa
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dc.rightsCC0 1.0 Universal*
dc.rights.accessrightsinfo:eu-repo/semantics/openAccess
dc.rights.coarhttp://purl.org/coar/access_right/c_abf2
dc.rights.localAbierto (Texto Completo)spa
dc.rights.urihttp://creativecommons.org/publicdomain/zero/1.0/*
dc.subject.keywordAcetaminophenspa
dc.subject.keywordWaste water treatmentspa
dc.subject.keywordHPLCspa
dc.subject.keywordAllium Cepa testspa
dc.subject.keywordEffective Concentrationspa
dc.subject.lembMosquitos-controlspa
dc.subject.lembSalud públicaspa
dc.subject.lembEpidemiologíaspa
dc.subject.lembAgentes antibacterialesspa
dc.subject.proposalAcetaminofénspa
dc.subject.proposalPlanta de Aguas Residualesspa
dc.subject.proposalHPLCspa
dc.subject.proposalconcentración efectivaspa
dc.subject.proposalMétodo Allium Cepaspa
dc.titleEvaluación de las concentraciones de acetaminofén presentes en la Planta de Tratamiento de Aguas Residuales de la Universidad Pontificia Bolivariana-Seccional Bucaramanga y su efecto tòxico sobre el Allium Cepaspa
dc.typemaster thesis
dc.type.categoryFormación de Recurso Humano para la Ctel: Trabajo de grado de Maestríaspa
dc.type.coarhttp://purl.org/coar/resource_type/c_bdcc
dc.type.coarversionhttp://purl.org/coar/version/c_ab4af688f83e57aa
dc.type.driveinfo:eu-repo/semantics/masterThesis
dc.type.localTesis de maestríaspa
dc.type.versioninfo:eu-repo/semantics/acceptedVersion

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