Computational modeling of the mechanical modulation of the growth plate by sustained loading
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2012-09-25
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Abstract
This paper presents a computational model that describes the growth of the bone
as a function of the proliferation and hypertrophy of chondrocytes in the growth
plate. We have included the effects of the mechanical loads on the sizes of the
proliferative and hypertrophic areas, the number of proliferative chondrocytes and
the final size of the hypertrophic chondrocytes. The validation of the model was
performed with experimental data published on other investigations about proximal
tibia of rats, subjected to sustained axial stresses of 0.1 MPa, 0.0 MPa, -0.1 MPa and
−0.2 MPa. Growth was simulated during 23 days, obtaining numerical errors between
2.77% and 3.73% with respect to experimental growth rates. The results obtained
show that the model adequately simulates the behavior of the growth plate and the
effect of mechanical loads over its cellular activity.