Geometric and mechanical properties evaluation of scaffolds for bone tissue applications designing by a reaction-diffusion models and manufactured with a material jetting system
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2016-10
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Abstract
Scaffolds are essential in bone tissue engineering, as they provide support to cells and growth
factors necessary to regenerate tissue. In addition, they meet the mechanical function of the bone
while it regenerates. Currently, the multiple methods for designing and manufacturing scaffolds are
based on regular structures from a unit cell that repeats in a given domain. However, these methods
do not resemble the actual structure of the trabecular bone which may work against osseous tissue
regeneration. To explore the design of porous structures with similar mechanical properties to
native bone, a geometric generation scheme from a reaction-diffusion model and its manufacturing
via a material jetting system is proposed. This article presents the methodology used, the geometric
characteristics and the modulus of elasticity of the scaffolds designed and manufactured. The
method proposed shows its potential to generate structures that allow to control the basic scaffold
properties for bone tissue engineering such as the width of the channels and porosity. The
mechanical properties of our scaffolds are similar to trabecular tissue present in vertebrae and tibia
bones. Tests on the manufactured scaffolds show that it is necessary to consider the orientation of
the object relative to the printing system because the channel geometry, mechanical properties and
roughness are heavily influenced by the position of the surface analyzed with respect to the printing
axis. A possible line for future work may be the establishment of a set of guidelines to consider the
effects of manufacturing processes in designing stages.
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Atribución-NoComercial-CompartirIgual 2.5 Colombia