Cytotoxic and Antifungal Activities of Diverse α-Naphthylamine Derivatives
Cargando...
Fecha
Director
Enlace al recurso
ORCID
Google Scholar
Cvlac
gruplac
Descripción Dominio:
Título de la revista
ISSN de la revista
Título del volumen
Editor
Compartir
Documentos PDF
Descripción
Abstract
Diverse α-naphthylamine derivatives were easily prepared from corresponding
aldimines derived from commercially available α-naphthaldehyde and anilines
or isomeric pyridinecarboxyaldehydes and α-naphthylamine. The secondary
amines obtained were tested as possible antifungal and cytotoxic agents. The
diverse N-aryl-N-[1-(1-naphthyl)but-3-enyl]amines obtained were active (IC50 <
10 µg/mL) against breast (MCF-7), non-small cell lung (H-460), and central
nervous system (SF-268) human cancer cell lines, while N-(pyridinylmethyl)-
naphthalen-1-amines resulted in activity against (MIC 25–32 µg/mL) some
human opportunistic pathogenic fungi including yeasts, hialohyphomycetes, and
dermatophytes.
Idioma
Palabras clave
Citación
Colecciones
Licencia Creative Commons
Atribución-NoComercial-CompartirIgual 2.5 Colombia