Cytotoxic and Antifungal Activities of Diverse α-Naphthylamine Derivatives

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dc.contributor.authorKouznetsov, Vladímir V.
dc.contributor.authorSortino, Maximiliano
dc.contributor.authorZacchino, Susana A.
dc.contributor.authorVargas Méndez, Leonor Y.
dc.contributor.authorGupta, Mahabir P.
dc.date.accessioned2020-02-03T11:51:22Z
dc.date.available2020-02-03T11:51:22Z
dc.date.issued2012-10-23
dc.description.abstractDiverse α-naphthylamine derivatives were easily prepared from corresponding aldimines derived from commercially available α-naphthaldehyde and anilines or isomeric pyridinecarboxyaldehydes and α-naphthylamine. The secondary amines obtained were tested as possible antifungal and cytotoxic agents. The diverse N-aryl-N-[1-(1-naphthyl)but-3-enyl]amines obtained were active (IC50 < 10 µg/mL) against breast (MCF-7), non-small cell lung (H-460), and central nervous system (SF-268) human cancer cell lines, while N-(pyridinylmethyl)- naphthalen-1-amines resulted in activity against (MIC 25–32 µg/mL) some human opportunistic pathogenic fungi including yeasts, hialohyphomycetes, and dermatophytes.spa
dc.description.domainhttp://unidadinvestigacion.usta.edu.cospa
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.3797/scipharm.1209-03spa
dc.identifier.urihttp://hdl.handle.net/11634/21360
dc.publisher.branchCRAI-USTA Bogotáspa
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dc.rightsAtribución-NoComercial-CompartirIgual 2.5 Colombia
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/2.5/co/
dc.subject.keywordα-Naphthylaminesspa
dc.subject.keywordAntifungal propertiesspa
dc.subject.keywordCytotoxic agentsspa
dc.titleCytotoxic and Antifungal Activities of Diverse α-Naphthylamine Derivativesspa
dc.type.categoryGeneración de Nuevo Conocimiento: Artículos publicados en revistas especializadas - Electrónicosspa

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