Estudio preliminar de liberación controlada de ibuprofeno empleando un hidrogel de quitosano magnético

Patiño Medina, Juliana María

Estudio preliminar de liberación controlada de ibuprofeno empleando un hidrogel de quitosano magnético

dc.contributor.advisor	Candela Soto, Angélica María
dc.contributor.advisor	Camargo García, Hernando Alberto
dc.contributor.advisor	Alvarado Rueda, Lizeth Johanna
dc.contributor.author	Patiño Medina, Juliana María
dc.date.accessioned	2020-09-04T16:40:10Z
dc.date.available	2020-09-04T16:40:10Z
dc.date.issued	2020-08-27
dc.description	Esta investigación presenta la síntesis de un composito a partir de un método híbrido de síntesis in situ de agregación de nanopartículas magnéticas al hidrogel de quitosano, al igual que la síntesis de un hidrogel de quitosano-glutaraldehído (HCG) por medio de agitación y gelificación, elaborados a partir del quitosano extraído del exoesqueleto de crustáceos. Se estudiaron los hidrogeles como posibles materiales alternativos en la liberación controlada del ibuprofeno, dicha prueba se elaboró a un pH 7.4 y 2.0, simulando pH del cuerpo humano, donde el HCG presentó mejor comportamiento. En la caracterización de los materiales se emplearon las técnicas analíticas: FTIR, XRD, SEM, TGA y RAMAN.	spa
dc.description.abstract	This research presents the synthesis of a composite from a hybrid in situ synthesis method of aggregation of magnetic nanoparticles to the chitosan hydrogel, as well as the synthesis of a chitosan-glutaraldehyde (HCG) hydrogel using agitation and gelation, made from chitosan extracted from the exoskeleton of crustaceans. Hydrogels were studied as possible alternative materials in the controlled release of ibuprofen, this test was carried out at pH 7.4 and 2.0, simulating the pH of the human body, where HCG showed better performance. In the characterization of the materials, the analytical techniques were used: FTIR, XRD, SEM, TGA, and RAMAN.	spa
dc.description.degreelevel	Pregrado	spa
dc.description.degreename	Químico Ambiental	spa
dc.description.domain	https://www.ustabuca.edu.co/	spa
dc.format.mimetype	application/pdf
dc.identifier.citation	Patiño Medina, J. M. (2020). Estudio preliminar de liberación controlada de ibuprofeno empleando un hidrogel de quitosano magnético [Tesis de pregrado]. Universidad Santo Tomás, Bucaramanga, Colombia.	spa
dc.identifier.instname	instname:Universidad Santo Tomás	spa
dc.identifier.reponame	reponame:Repositorio Institucional Universidad Santo Tomás	spa
dc.identifier.repourl	repourl:https://repository.usta.edu.co	spa
dc.identifier.uri	http://hdl.handle.net/11634/29434
dc.language.iso	spa
dc.publisher	Universidad Santo Tomás	spa
dc.publisher.branch	CRAI-USTA Bucaramanga	spa
dc.publisher.faculty	Facultad de Química Ambiental	spa
dc.publisher.program	Pregrado Química Ambiental	spa
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dc.rights	Atribución-NoComercial-SinDerivadas 2.5 Colombia
dc.rights	Atribución-NoComercial-SinDerivadas 2.5 Colombia
dc.rights	Atribución-NoComercial-SinDerivadas 2.5 Colombia
dc.rights.accessrights	info:eu-repo/semantics/openAccess
dc.rights.coar	http://purl.org/coar/access_right/c_abf2
dc.rights.local	Abierto (Texto Completo)	spa
dc.rights.uri	http://creativecommons.org/licenses/by-nc-nd/2.5/co/
dc.subject.keyword	Chitosan	spa
dc.subject.keyword	Controlled drug delivery	spa
dc.subject.keyword	Hydrogel	spa
dc.subject.keyword	Ibuprofen	spa
dc.subject.keyword	Magnetic nanoparticles	spa
dc.subject.lemb	Química combinatoria	spa
dc.subject.lemb	Química farmacéutica	spa
dc.subject.lemb	Geles	spa
dc.subject.lemb	Nanopartículas	spa
dc.subject.proposal	Hidrogel	spa
dc.subject.proposal	Ibuprofeno	spa
dc.subject.proposal	Liberación controlada de fármacos	spa
dc.subject.proposal	Nanopartículas magnéticas	spa
dc.subject.proposal	Quitosano	spa
dc.title	Estudio preliminar de liberación controlada de ibuprofeno empleando un hidrogel de quitosano magnético	spa
dc.type	bachelor thesis
dc.type.category	Formación de Recurso Humano para la Ctel: Trabajo de grado de Pregrado	spa
dc.type.coar	http://purl.org/coar/resource_type/c_7a1f
dc.type.coarversion	http://purl.org/coar/version/c_ab4af688f83e57aa
dc.type.drive	info:eu-repo/semantics/bachelorThesis
dc.type.local	Tesis de pregrado	spa
dc.type.version	info:eu-repo/semantics/acceptedVersion