Influencia de la forma cristalina de los medicamentos de omeprazol en la salud pública

Abstract

The active ingredient of drugs can have different crystalline forms called polymorphs which have different pharmacological properties between them. The control of the polymorphism is vital importance because the supply of a forms crystalline inadequate carries to problems of human’s health, because to the toxicity or the stagnation of the medicament. It is for this reason, which in the pharmaceutical industry must controlled the process of crystallization of the active ingredient and the variables that this implies (temperature, solvent, agitation, etc.). The generic´s industry has penetrated on the world market, when achieving a high place but affecting human’s health , because principally to the increase of collateral effects that it provokes to supply a inadequate prescription. For this, serious affectations exist to the public health, because these medicines do not present the same guarantee that original (patented) where the population of the lowest social stratum are most affected by the consumption of generic sayings due to small or void possibility of ability of buy the original medicines. It is for this reason that it intends to conduct a comparative crystallographic study of six brands of generic omeprazole, with the purpose of identifying the crystalline form of each active ingredient, excipients and the impact on public health of consuming low quality medicines. The methodology is based on the technique of X-ray diffraction of polycrystalline samples, in conjunction with analysis programs implemented by this method.