Función endotelial y lipemia postprandial en adultos con presencia de criterios asociados a síndrome metabólico: Efecto del estado nutricional

Abstract

Introduction: Postprandial lipemia (PL) is characterized by an increase in triglyceride-rich lipoproteins and several studies described as a factor determining the metabolic health of an individual. The objective of the present study was to quantify the contribution of overweigth to the magnitude of LP in 33 normolipidemic subjects (n=20, overweight, n=13, eutrophic, 66% male, mean age 31.2±7.6 years). Method: A cross-sectional study. Fasting (0 min) and postprandial changes (60, 120, 180, and 240min) in vascular endothelial function using flow-mediated dilatation (FMD) and brachial pulse wave velocity (bPWV), lipid profile, Log TG/HDL-cholesterol, blood glucose and blood pressure who underwent a standardized breakfast with a high-fat (79% Kcal/fat) content. A CVD risk score was computed as a measure of the overall CVD risk profile. Baseline FMD and bPWV were 6.9±5.9% and 7.0±0.8 m/s, respectively. LP reduced FMD in 19.2% at 60min (5,9±1,5%) and 240min (3.7±1.2%), p<0.04 respectively. Results: This finding was associated to an increased in bPWV (p<0.05). Basal CVD risk score and bPWV were higher in overweight (p<0.05). The total increase (Δ-Log TG/HDL-cholesterol and Δ-bPWV), corresponding to the difference between the maximum and the basal was higer in overweight (20.2±30.5 vs. 58.1±21.4, p<0.001) and (6.4±0.2 m/s vs. 7.0±0.1 m/s, p<0.001), respectively. Conclusion: The behavior of LP state is different in eutrophic and overweight normolipidemic subjects.