Cantharidin-based small molecules as potential therapeutic agents
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Abstract
Chemical and pharmacological information on cantharidin-based SMs was analyzed. The review
summarizes new facts about blister beetles metabolites for the period 2006-2012. General synthetic
approaches to cantharidin-based small molecules as well as its chemical transformations and the
biological activities related with cantharidin, norcantharidin, cantharidimide and norcantharimide
analogues, specially their inhibitory activity of phosphoprotein phosphatases in cancer treatment,
were discussed in this mini review that could help to design new small molecules modulators for
other biological models.
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Atribución-NoComercial-CompartirIgual 2.5 Colombia