Efecto antiinflamatorio del Cannabidiol en patologías orales una revisión sistemática de literatura

Abstract

Introduction: oral neoplastic lesions frequently develop at the level of non-keratinized mucosal areas, resulting in more vulnerability to damage and being mostly affected by cancer therapy, compared to other structures. Therefore, the use of Cannabidiol in these patients has brought great benefits such as immune, inflammatory and analgesic modulation, since scientific evidence has shown that it has good safety and an adequate tolerability profile. Objective: to determine the anti-inflammatory effect of Cannabidiol in oral pathologies, through the systematic review of health databases from the first period of 2011 to the first period of 2022. Materials and methods: systematic review of the literature that compiled articles from scientific journals of seven databases (Scopus, Web of science, Google Scholar, Pubmed, Science Direct, VHL odontology, Oral Dentistry) that contained information on the effects of Cannabidiol on oral pathologies, in a time interval between the first period of 2011 to the first period of 2021 and with other selection criteria. The risk of bias was assessed based on the Cochrane checklist. Results: the number of full text articles evaluated for their eligibility were four. where it can be observed that there was effectiveness with respect to the relief of recurrent aphthous ulcers, as a bactericide of bacterial plaque and as a muscle relaxant for myofascial pain of the masseter. It did not show efficacy as an analgesic for acute pain after third molar extraction. Three of the four articles had a low risk of bias. Conclusion: with the help of these clinical trials, it was determined that CBD is effective in relieving recurrent aphthous ulcers, as a bactericide against bacterial plaque, and as a muscle relaxant for myofascial pain in the masseter.